NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori
Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. Results: A case–control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal–type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41–5.13, p = 0.0026). The association was not statistically significant in diffuse–type gastric cancer cases (OR = 1.26, 95% CI 0.63–2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80–3.36, p = 0.0019), in particular for intestinal–type gastric cancer cases (OR = 7.16, 95% CI 2.40–21.33, p = 4.1 × 10−4) but not among diffuse–type gastric cancer cases (OR = 3.39, 95% CI 1.13–0.10, p = 0.03). Conclusions: NOD1 rs2075820 increases the risk of intestinal–type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad de Biología de Chile
2021
|
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0716-97602021000100213 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0716-976020210001002132022-03-28NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pyloriGonzalez–Hormazabal,PatricioPelaez,DianaMusleh,MaherBustamante,MarcoStambuk,JuanPisano,RaulValladares,HectorLanzarini,EnriqueChiong,HectorSuazo,JoseQuiñones,Luis A.Varela,Nelson M.Castro,V. GonzaloJara,LilianBerger,Zoltan Gastric cancer Polymorphism Association study H. pylori NOD1 E266K Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. Results: A case–control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal–type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41–5.13, p = 0.0026). The association was not statistically significant in diffuse–type gastric cancer cases (OR = 1.26, 95% CI 0.63–2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80–3.36, p = 0.0019), in particular for intestinal–type gastric cancer cases (OR = 7.16, 95% CI 2.40–21.33, p = 4.1 × 10−4) but not among diffuse–type gastric cancer cases (OR = 3.39, 95% CI 1.13–0.10, p = 0.03). Conclusions: NOD1 rs2075820 increases the risk of intestinal–type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.54 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213en10.1186/s40659-021-00336-4 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Chile |
| countrycode |
CL |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-cl |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Gonzalez–Hormazabal,Patricio Pelaez,Diana Musleh,Maher Bustamante,Marco Stambuk,Juan Pisano,Raul Valladares,Hector Lanzarini,Enrique Chiong,Hector Suazo,Jose Quiñones,Luis A. Varela,Nelson M. Castro,V. Gonzalo Jara,Lilian Berger,Zoltan |
| spellingShingle |
Gonzalez–Hormazabal,Patricio Pelaez,Diana Musleh,Maher Bustamante,Marco Stambuk,Juan Pisano,Raul Valladares,Hector Lanzarini,Enrique Chiong,Hector Suazo,Jose Quiñones,Luis A. Varela,Nelson M. Castro,V. Gonzalo Jara,Lilian Berger,Zoltan NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| author_facet |
Gonzalez–Hormazabal,Patricio Pelaez,Diana Musleh,Maher Bustamante,Marco Stambuk,Juan Pisano,Raul Valladares,Hector Lanzarini,Enrique Chiong,Hector Suazo,Jose Quiñones,Luis A. Varela,Nelson M. Castro,V. Gonzalo Jara,Lilian Berger,Zoltan |
| author_sort |
Gonzalez–Hormazabal,Patricio |
| title |
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| title_short |
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| title_full |
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| title_fullStr |
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| title_full_unstemmed |
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI–positive H. pylori |
| title_sort |
nod1 rs2075820 (p.e266k) polymorphism is associated with gastric cancer among individuals infected with cagpai–positive h. pylori |
| description |
Abstract Background: Helicobacter pylori is detected by pathogen recognition receptors including toll–like receptors (TLR) and nucleotide–binding oligomerization domain (NOD)–like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. Results: A case–control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal–type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41–5.13, p = 0.0026). The association was not statistically significant in diffuse–type gastric cancer cases (OR = 1.26, 95% CI 0.63–2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80–3.36, p = 0.0019), in particular for intestinal–type gastric cancer cases (OR = 7.16, 95% CI 2.40–21.33, p = 4.1 × 10−4) but not among diffuse–type gastric cancer cases (OR = 3.39, 95% CI 1.13–0.10, p = 0.03). Conclusions: NOD1 rs2075820 increases the risk of intestinal–type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI. |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2021 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100213 |
| work_keys_str_mv |
AT gonzalez8211hormazabalpatricio nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT pelaezdiana nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT muslehmaher nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT bustamantemarco nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT stambukjuan nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT pisanoraul nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT valladareshector nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT lanzarinienrique nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT chionghector nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT suazojose nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT quinonesluisa nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT varelanelsonm nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT castrovgonzalo nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT jaralilian nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori AT bergerzoltan nod1rs2075820pe266kpolymorphismisassociatedwithgastriccanceramongindividualsinfectedwithcagpai8211positivehpylori |
| _version_ |
1755990977884979200 |