Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes
Carotenoids are efficient antioxidants that are of great importance for human health. Lutein and zeaxanthin are carotinoids present in high concentrations in the human retina which are involved in the photoprotection of the human eye. Lutein may also protect the skin from ultraviolet (UV)-induced damage. The present study investigated the protective effect of lutein extracted from yellow silk cocoons of Bombyx mori on human keratinocytes against UVB irradiation. A human keratinocyte cell line and primary human keratinocytes were used to investigate the UVB protection effects of silk lutein and plant lutein. Silk lutein showed no cytotoxicity to keratinocytes. Treatment with silk lutein prior to UVB irradiation enhanced cell viability and cell proliferation, and reduced cell apoptosis. The protective effects of silk lutein may be superior to those of plant lutein. Silk lutein may have a benefit for protection of keratinocytes against UVB-irradiation.
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Sociedad de Biología de Chile
2013
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oai:scielo:S0716-976020130001000062014-09-08Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytesPongcharoen,SutatipWarnnissorn,PrateepLertkajornsin,OngartLimpeanchob,NanteetipSutheerawattananonda,Manote Silk lutein keratinocytes UV apoptosis Carotenoids are efficient antioxidants that are of great importance for human health. Lutein and zeaxanthin are carotinoids present in high concentrations in the human retina which are involved in the photoprotection of the human eye. Lutein may also protect the skin from ultraviolet (UV)-induced damage. The present study investigated the protective effect of lutein extracted from yellow silk cocoons of Bombyx mori on human keratinocytes against UVB irradiation. A human keratinocyte cell line and primary human keratinocytes were used to investigate the UVB protection effects of silk lutein and plant lutein. Silk lutein showed no cytotoxicity to keratinocytes. Treatment with silk lutein prior to UVB irradiation enhanced cell viability and cell proliferation, and reduced cell apoptosis. The protective effects of silk lutein may be superior to those of plant lutein. Silk lutein may have a benefit for protection of keratinocytes against UVB-irradiation.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.46 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100006en10.4067/S0716-97602013000100006 |
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Pongcharoen,Sutatip Warnnissorn,Prateep Lertkajornsin,Ongart Limpeanchob,Nanteetip Sutheerawattananonda,Manote |
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Pongcharoen,Sutatip Warnnissorn,Prateep Lertkajornsin,Ongart Limpeanchob,Nanteetip Sutheerawattananonda,Manote Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
author_facet |
Pongcharoen,Sutatip Warnnissorn,Prateep Lertkajornsin,Ongart Limpeanchob,Nanteetip Sutheerawattananonda,Manote |
author_sort |
Pongcharoen,Sutatip |
title |
Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
title_short |
Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
title_full |
Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
title_fullStr |
Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
title_full_unstemmed |
Protective effect of silk lutein on ultraviolet B-irradiated human keratinocytes |
title_sort |
protective effect of silk lutein on ultraviolet b-irradiated human keratinocytes |
description |
Carotenoids are efficient antioxidants that are of great importance for human health. Lutein and zeaxanthin are carotinoids present in high concentrations in the human retina which are involved in the photoprotection of the human eye. Lutein may also protect the skin from ultraviolet (UV)-induced damage. The present study investigated the protective effect of lutein extracted from yellow silk cocoons of Bombyx mori on human keratinocytes against UVB irradiation. A human keratinocyte cell line and primary human keratinocytes were used to investigate the UVB protection effects of silk lutein and plant lutein. Silk lutein showed no cytotoxicity to keratinocytes. Treatment with silk lutein prior to UVB irradiation enhanced cell viability and cell proliferation, and reduced cell apoptosis. The protective effects of silk lutein may be superior to those of plant lutein. Silk lutein may have a benefit for protection of keratinocytes against UVB-irradiation. |
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Sociedad de Biología de Chile |
publishDate |
2013 |
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100006 |
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