Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
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Sociedad de Biología de Chile
2011
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oai:scielo:S0716-976020110001000032011-09-01Location matters: the endoplasmic reticulum and protein trafficking in dendritesRamírez,Omar AHärtel,SteffenCouve,Andrés endoplasmic reticulum protein trafficking dendrites neuron Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003en10.4067/S0716-97602011000100003 |
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| author |
Ramírez,Omar A Härtel,Steffen Couve,Andrés |
| spellingShingle |
Ramírez,Omar A Härtel,Steffen Couve,Andrés Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| author_facet |
Ramírez,Omar A Härtel,Steffen Couve,Andrés |
| author_sort |
Ramírez,Omar A |
| title |
Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| title_short |
Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| title_full |
Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
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Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| title_full_unstemmed |
Location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| title_sort |
location matters: the endoplasmic reticulum and protein trafficking in dendrites |
| description |
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity. |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003 |
| work_keys_str_mv |
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