Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens
Angiogenesis is a complex multi-step process of neovascularization arising from preexisting blood vessels whose generation is regulated by pro- and anti-angiogenic factors. Both Trypanosoma cruzi calreticulin (TcCRT) and its human counterpart (HuCRT) are antiangiogenic. This is the first report where the TcCRT and HuCRT anti-angiogenic properties are compared in vivo. In the chick embryonic chorioallantoid membrane assay (CAM) and at equimolar concentrations, TcCRT displayed significantly higher antiangiogenic activities than its human counterpart. LPS had marginal effects at the concentrations present in the recombinant protein preparations and the TcCRT antiangiogenic effects were largely inhibited by specific polyclonal antibodies, thus, reinforcing the fact that the observed TcCRT effects can be attributed to the parasite-derived molecule and not to the endotoxin. The antiangiogenic TcCRT effects correlate with its anti-tumor in vivo effects, as recently shown in our laboratory.
Main Authors: | Toledo,Victor, Ramírez,Galia, Valck,Carolina, López,Nandy, Ribeiro,Carolina H, Maldonado,Ismael, Aguilar,Lorena, Lemus,David, Ferreira,Arturo |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedad de Biología de Chile
2010
|
Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300004 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
DEFINIENDO HOMO SAPIENS-SAPIENS: APROXIMACIÓN ANTROPOLÓGICA
by: Valdebenito,Carolina
Published: (2007) -
Homo sapiens in the Middle Pleistocene and the evidence of Homo sapiens' evolution
by: Leakey, Louis S.B. -
The Origin of Homo sapiens
by: Symposium on the Origin of Homo Sapiens, Paris, 1969 -
China in the period of 'Homo sapiens sapiens' to the beginnings of food production
by: Jia Lanpo, et al. -
Homo sapiens, that strange paradox
by: Bovet, Daniel