Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix

Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix

Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (HPV) infection status. Indirect immunofluorescence was used to study the expression of IL-2, IL-2R and IL-10 in human cervical samples from 50 patients and 9 normal controls. Serum IL-2, IL-2R and IL-10 were measured by ELISA and HPV DNA and HPV types were identified by PCR. Increased number of IL-2, IL-2R and IL-10 positive cells were observed in the cervix from patients with CIN, associated with the grades of dysplasia. A significant correlation was observed between IL-2 and IL-2R (p>0.0001), IL-2 and IL-10 (p > 0,0001), as well as IL-10 and IL-2R (p> 0.0001). Twenty percent of patients were HPV positive and 84 % of those patients were tissue cytokine positive. These results suggest that IL-2, IL-2R and IL-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.

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Main Authors: Mindiola,Raimy, Callejas,Diana, Núñez-Troconis,José, Araujo,Mary, Delgado,Mariela, Mosquera,Jesús
Format: Digital revista
Language:English
Published: Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia 2008
Online Access:http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332008000400008
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spelling oai:scielo:S0535-513320080004000082009-02-13Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervixMindiola,RaimyCallejas,DianaNúñez-Troconis,JoséAraujo,MaryDelgado,MarielaMosquera,Jesús IL-2 IL-2 receptor IL-10 premalignant lesions cervix Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (HPV) infection status. Indirect immunofluorescence was used to study the expression of IL-2, IL-2R and IL-10 in human cervical samples from 50 patients and 9 normal controls. Serum IL-2, IL-2R and IL-10 were measured by ELISA and HPV DNA and HPV types were identified by PCR. Increased number of IL-2, IL-2R and IL-10 positive cells were observed in the cervix from patients with CIN, associated with the grades of dysplasia. A significant correlation was observed between IL-2 and IL-2R (p>0.0001), IL-2 and IL-10 (p > 0,0001), as well as IL-10 and IL-2R (p> 0.0001). Twenty percent of patients were HPV positive and 84 % of those patients were tissue cytokine positive. These results suggest that IL-2, IL-2R and IL-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.info:eu-repo/semantics/openAccessInstituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del ZuliaInvestigación Clínica v.49 n.4 20082008-12-01info:eu-repo/semantics/articletext/htmlhttp://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332008000400008en
institution SCIELO
collection OJS
country Venezuela
countrycode VE
component Revista
access En linea
databasecode rev-scielo-ve
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Mindiola,Raimy
Callejas,Diana
Núñez-Troconis,José
Araujo,Mary
Delgado,Mariela
Mosquera,Jesús
spellingShingle Mindiola,Raimy
Callejas,Diana
Núñez-Troconis,José
Araujo,Mary
Delgado,Mariela
Mosquera,Jesús
Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
author_facet Mindiola,Raimy
Callejas,Diana
Núñez-Troconis,José
Araujo,Mary
Delgado,Mariela
Mosquera,Jesús
author_sort Mindiola,Raimy
title Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
title_short Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
title_full Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
title_fullStr Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
title_full_unstemmed Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
title_sort increased number of il-2, il-2 receptor and il-10 positive cells in premalignant lesions of the cervix
description Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (HPV) infection status. Indirect immunofluorescence was used to study the expression of IL-2, IL-2R and IL-10 in human cervical samples from 50 patients and 9 normal controls. Serum IL-2, IL-2R and IL-10 were measured by ELISA and HPV DNA and HPV types were identified by PCR. Increased number of IL-2, IL-2R and IL-10 positive cells were observed in the cervix from patients with CIN, associated with the grades of dysplasia. A significant correlation was observed between IL-2 and IL-2R (p>0.0001), IL-2 and IL-10 (p > 0,0001), as well as IL-10 and IL-2R (p> 0.0001). Twenty percent of patients were HPV positive and 84 % of those patients were tissue cytokine positive. These results suggest that IL-2, IL-2R and IL-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.
publisher Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia
publishDate 2008
url http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332008000400008
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AT callejasdiana increasednumberofil2il2receptorandil10positivecellsinpremalignantlesionsofthecervix
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AT mosquerajesus increasednumberofil2il2receptorandil10positivecellsinpremalignantlesionsofthecervix
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