Use of sugammadex in acute intermittent porphyria
Abstract: Porphyrias are a group of rare diseases, which include acute intermittent porphyria. It is essential for the anesthesiologist to identify acute porphyrias and to recognize a porphyric crises. These can be triggered by several factors, which can be present throughout the perioperative period. A 70-year-old male, ASA III, with a personal history of acute intermittent porphyria and ischemic heart disease, scheduled for laparoscopic sigmoidectomy. Prolonged fasting, dehydration and potentially porphyrinogenic drugs were avoided. General anesthesia was induced with fentanyl, lidocaine, propofol and rocuronium and maintained with desflurane. The decision to reverse the neuromuscular blockade with sugammadex was considered due to the benefits over risks of this drug when compared to neostigmine (associated with atropine) and the description of its use without harm in two cases of variegate porphyria. The following paper emphasize the importance of careful anesthetic management throughout the perioperative period and describe a case of successful reversal of neuromuscular block with sugammadex, highlighting this case as the first case reported of its use in acute intermittent porphyria.
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Colegio Mexicano de Anestesiología A.C.
2021
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oai:scielo:S0484-790320210003002292021-09-29Use of sugammadex in acute intermittent porphyriaTinoco,JoanaEloy,AndréRegufe,RitaRosinha,DanielaTaleco,TiagoSilva-Duarte,João Sugammadex acute intermittent porphyria anesthesia management case report Abstract: Porphyrias are a group of rare diseases, which include acute intermittent porphyria. It is essential for the anesthesiologist to identify acute porphyrias and to recognize a porphyric crises. These can be triggered by several factors, which can be present throughout the perioperative period. A 70-year-old male, ASA III, with a personal history of acute intermittent porphyria and ischemic heart disease, scheduled for laparoscopic sigmoidectomy. Prolonged fasting, dehydration and potentially porphyrinogenic drugs were avoided. General anesthesia was induced with fentanyl, lidocaine, propofol and rocuronium and maintained with desflurane. The decision to reverse the neuromuscular blockade with sugammadex was considered due to the benefits over risks of this drug when compared to neostigmine (associated with atropine) and the description of its use without harm in two cases of variegate porphyria. The following paper emphasize the importance of careful anesthetic management throughout the perioperative period and describe a case of successful reversal of neuromuscular block with sugammadex, highlighting this case as the first case reported of its use in acute intermittent porphyria.info:eu-repo/semantics/openAccessColegio Mexicano de Anestesiología A.C.Revista mexicana de anestesiología v.44 n.3 20212021-09-01info:eu-repo/semantics/reporttext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0484-79032021000300229en |
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Tinoco,Joana Eloy,André Regufe,Rita Rosinha,Daniela Taleco,Tiago Silva-Duarte,João |
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Tinoco,Joana Eloy,André Regufe,Rita Rosinha,Daniela Taleco,Tiago Silva-Duarte,João Use of sugammadex in acute intermittent porphyria |
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Tinoco,Joana Eloy,André Regufe,Rita Rosinha,Daniela Taleco,Tiago Silva-Duarte,João |
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Tinoco,Joana |
title |
Use of sugammadex in acute intermittent porphyria |
title_short |
Use of sugammadex in acute intermittent porphyria |
title_full |
Use of sugammadex in acute intermittent porphyria |
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Use of sugammadex in acute intermittent porphyria |
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Use of sugammadex in acute intermittent porphyria |
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use of sugammadex in acute intermittent porphyria |
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Abstract: Porphyrias are a group of rare diseases, which include acute intermittent porphyria. It is essential for the anesthesiologist to identify acute porphyrias and to recognize a porphyric crises. These can be triggered by several factors, which can be present throughout the perioperative period. A 70-year-old male, ASA III, with a personal history of acute intermittent porphyria and ischemic heart disease, scheduled for laparoscopic sigmoidectomy. Prolonged fasting, dehydration and potentially porphyrinogenic drugs were avoided. General anesthesia was induced with fentanyl, lidocaine, propofol and rocuronium and maintained with desflurane. The decision to reverse the neuromuscular blockade with sugammadex was considered due to the benefits over risks of this drug when compared to neostigmine (associated with atropine) and the description of its use without harm in two cases of variegate porphyria. The following paper emphasize the importance of careful anesthetic management throughout the perioperative period and describe a case of successful reversal of neuromuscular block with sugammadex, highlighting this case as the first case reported of its use in acute intermittent porphyria. |
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Colegio Mexicano de Anestesiología A.C. |
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2021 |
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http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0484-79032021000300229 |
work_keys_str_mv |
AT tinocojoana useofsugammadexinacuteintermittentporphyria AT eloyandre useofsugammadexinacuteintermittentporphyria AT reguferita useofsugammadexinacuteintermittentporphyria AT rosinhadaniela useofsugammadexinacuteintermittentporphyria AT talecotiago useofsugammadexinacuteintermittentporphyria AT silvaduartejoao useofsugammadexinacuteintermittentporphyria |
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