BIOLOGICALLY ACTIVE COMPOUNDS FROM CHILEAN PROPOLIS

A propolis sample from the western Andean slopes of the Maule Region, Chile, showed free radical scavenging activity and inhibited the enzyme xanthine oxidase "in vitro". Six flavonoids were isolated as the main active constituents of the sample. 5,7-dihydroxyflavone 4, 3,5,7-trihydroxyflavone 6 and 5,7-dihydroxyflavanone 1 displayed a strong free radical scavenging effect. At 50 mg/ml, compounds 6 and 1 inhibited the enzyme xanthine oxidase by 95 and 86%, respectively.

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Bibliographic Details
Main Authors: ASTUDILLO S.,LUIS, AVILA R.,FERNANDO, MORRISON A.,ROBERTO, GUTIERREZ C.,MARGARITA, BASTIDA,JAUME, CODINA,CARLOS, SCHMEDA-HIRSCHMANN,GUILLERMO
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2000
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442000000400008
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Summary:A propolis sample from the western Andean slopes of the Maule Region, Chile, showed free radical scavenging activity and inhibited the enzyme xanthine oxidase "in vitro". Six flavonoids were isolated as the main active constituents of the sample. 5,7-dihydroxyflavone 4, 3,5,7-trihydroxyflavone 6 and 5,7-dihydroxyflavanone 1 displayed a strong free radical scavenging effect. At 50 mg/ml, compounds 6 and 1 inhibited the enzyme xanthine oxidase by 95 and 86%, respectively.