Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,

Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,

Abstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.

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Main Authors: Sampaio,Raimunda Nonata Ribeiro, Ferreira,Marina Freitas, Martins,Sofia Sales, Motta,Jorgeth de Oliveira Carneiro da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Dermatologia 2021
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602
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spelling oai:scielo:S0365-059620210005006022021-10-14Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,Sampaio,Raimunda Nonata RibeiroFerreira,Marina FreitasMartins,Sofia SalesMotta,Jorgeth de Oliveira Carneiro da Allopurinol Antimony Recurrence Therapy Diffuse cutaneous leishmaniasis Abstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.96 n.5 20212021-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602en10.1016/j.abd.2021.03.003
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Sampaio,Raimunda Nonata Ribeiro
Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
spellingShingle Sampaio,Raimunda Nonata Ribeiro
Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
author_facet Sampaio,Raimunda Nonata Ribeiro
Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
author_sort Sampaio,Raimunda Nonata Ribeiro
title Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_short Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_full Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_fullStr Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_full_unstemmed Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_sort successful treatment of diffuse cutaneous leishmaniasis caused by leishmania amazonensis,
description Abstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.
publisher Sociedade Brasileira de Dermatologia
publishDate 2021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602
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AT martinssofiasales successfultreatmentofdiffusecutaneousleishmaniasiscausedbyleishmaniaamazonensis
AT mottajorgethdeoliveiracarneiroda successfultreatmentofdiffusecutaneousleishmaniasiscausedbyleishmaniaamazonensis
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