Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis

Abstract Background: The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. Objective: The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during the recent 15 years with meta-analysis. Methods: We retrospectively reviewed Chinese literature reporting severe cutaneous adverse drug reactions and collecting data from 2000 to 2015, which were in accordance with our inclusion criteria. All included data were analyzed with the Launch Open Meta-Analyst software. Results: Twenty-five articles involving 928 cases with severe cutaneous adverse drug reactions were included. Men to women ratio was 1.14:1. Twenty-one per cent of the patients had drug allergy history. Antibiotics (26.0%), sedative hypnotics and anticonvulsants (21.6%), and antipyretic analgesics (17.1%) were the most common causative drugs. The most frequent clinical subtype was Stevens-Johnson syndrome (50.1%), followed by toxic epidermal necrolysis (25.4%), exfoliative dermatitis (21.0%) and drug-induced hypersensitivity syndrome (1.6%). In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever (73%), and blood routine abnormality (66.7%). Study limitations: This meta-analysis is limited by its retrospective design and by its methodological variation. Conclusion: The most common causative drugs were antibiotics and sedative hypnotics and anticonvulsants. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions. In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever, mucosal lesion, and hematologic abnormalities.

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Main Authors: Deng,Qiancheng, Fang,Xia, Zeng,Qinghai, Lu,Jianyun, Jing,Chen, Huang,Jinhua
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Dermatologia 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000300345
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spelling oai:scielo:S0365-059620170003003452017-09-13Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysisDeng,QianchengFang,XiaZeng,QinghaiLu,JianyunJing,ChenHuang,Jinhua Drug eruptions Meta-analysis Dermatitis Abstract Background: The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. Objective: The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during the recent 15 years with meta-analysis. Methods: We retrospectively reviewed Chinese literature reporting severe cutaneous adverse drug reactions and collecting data from 2000 to 2015, which were in accordance with our inclusion criteria. All included data were analyzed with the Launch Open Meta-Analyst software. Results: Twenty-five articles involving 928 cases with severe cutaneous adverse drug reactions were included. Men to women ratio was 1.14:1. Twenty-one per cent of the patients had drug allergy history. Antibiotics (26.0%), sedative hypnotics and anticonvulsants (21.6%), and antipyretic analgesics (17.1%) were the most common causative drugs. The most frequent clinical subtype was Stevens-Johnson syndrome (50.1%), followed by toxic epidermal necrolysis (25.4%), exfoliative dermatitis (21.0%) and drug-induced hypersensitivity syndrome (1.6%). In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever (73%), and blood routine abnormality (66.7%). Study limitations: This meta-analysis is limited by its retrospective design and by its methodological variation. Conclusion: The most common causative drugs were antibiotics and sedative hypnotics and anticonvulsants. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions. In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever, mucosal lesion, and hematologic abnormalities.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.92 n.3 20172017-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000300345en10.1590/abd1806-4841.20175171
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Deng,Qiancheng
Fang,Xia
Zeng,Qinghai
Lu,Jianyun
Jing,Chen
Huang,Jinhua
spellingShingle Deng,Qiancheng
Fang,Xia
Zeng,Qinghai
Lu,Jianyun
Jing,Chen
Huang,Jinhua
Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
author_facet Deng,Qiancheng
Fang,Xia
Zeng,Qinghai
Lu,Jianyun
Jing,Chen
Huang,Jinhua
author_sort Deng,Qiancheng
title Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
title_short Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
title_full Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
title_fullStr Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
title_full_unstemmed Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
title_sort severe cutaneous adverse drug reactions of chinese inpatients: a meta-analysis
description Abstract Background: The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. Objective: The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during the recent 15 years with meta-analysis. Methods: We retrospectively reviewed Chinese literature reporting severe cutaneous adverse drug reactions and collecting data from 2000 to 2015, which were in accordance with our inclusion criteria. All included data were analyzed with the Launch Open Meta-Analyst software. Results: Twenty-five articles involving 928 cases with severe cutaneous adverse drug reactions were included. Men to women ratio was 1.14:1. Twenty-one per cent of the patients had drug allergy history. Antibiotics (26.0%), sedative hypnotics and anticonvulsants (21.6%), and antipyretic analgesics (17.1%) were the most common causative drugs. The most frequent clinical subtype was Stevens-Johnson syndrome (50.1%), followed by toxic epidermal necrolysis (25.4%), exfoliative dermatitis (21.0%) and drug-induced hypersensitivity syndrome (1.6%). In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever (73%), and blood routine abnormality (66.7%). Study limitations: This meta-analysis is limited by its retrospective design and by its methodological variation. Conclusion: The most common causative drugs were antibiotics and sedative hypnotics and anticonvulsants. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions. In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever, mucosal lesion, and hematologic abnormalities.
publisher Sociedade Brasileira de Dermatologia
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000300345
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