Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Abstract Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.

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Main Authors: Quaresma,Maria Victória, Bernardes Filho,Fred, Hezel,Janaína, Peretti,Murilo Calvo, Kac,Bernard Kawa, Azulay-Abulafia,Luna
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Dermatologia 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700051
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spelling oai:scielo:S0365-059620150007000512015-11-19Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agentQuaresma,Maria VictóriaBernardes Filho,FredHezel,JanaínaPeretti,Murilo CalvoKac,Bernard KawaAzulay-Abulafia,Luna Dapsone Hepatitis Pemphigus Prednisone Abstract Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.90 n.3 suppl.1 20152015-06-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700051en10.1590/abd1806-4841.20153408
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Quaresma,Maria Victória
Bernardes Filho,Fred
Hezel,Janaína
Peretti,Murilo Calvo
Kac,Bernard Kawa
Azulay-Abulafia,Luna
spellingShingle Quaresma,Maria Victória
Bernardes Filho,Fred
Hezel,Janaína
Peretti,Murilo Calvo
Kac,Bernard Kawa
Azulay-Abulafia,Luna
Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
author_facet Quaresma,Maria Victória
Bernardes Filho,Fred
Hezel,Janaína
Peretti,Murilo Calvo
Kac,Bernard Kawa
Azulay-Abulafia,Luna
author_sort Quaresma,Maria Victória
title Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_short Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_full Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_fullStr Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_full_unstemmed Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
title_sort dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent
description Abstract Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
publisher Sociedade Brasileira de Dermatologia
publishDate 2015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700051
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AT hezeljanaina dapsoneinthetreatmentofpemphigusvulgarisadverseeffectsanditsimportanceasacorticosteroidsparingagent
AT perettimurilocalvo dapsoneinthetreatmentofpemphigusvulgarisadverseeffectsanditsimportanceasacorticosteroidsparingagent
AT kacbernardkawa dapsoneinthetreatmentofpemphigusvulgarisadverseeffectsanditsimportanceasacorticosteroidsparingagent
AT azulayabulafialuna dapsoneinthetreatmentofpemphigusvulgarisadverseeffectsanditsimportanceasacorticosteroidsparingagent
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