Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

Insulin, a crucial therapeutic agent for diabetes mellitus, has been rarely associated with hypersensitivity events. We present a 69-year-old type-2 diabetic patient with urticariform lesions on the sites of subcutaneous injection of insulin. The patient denied any known allergies, except for an unspecific cutaneous reaction after intramuscular penicillin administration in childhood. Prick tests revealed positive reactions to all tested human insulins and insulin analogues. Serum IgE levels were above normal range and RAST tests were positive for human, bovine and porcine insulins, as well as beta-lactams. Type 1 IgEmediated allergy to insulin analogues demands a prompt diagnosis and represents a significant therapeutic challenge in diabetic patients.

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Main Authors: Andrade,Pedro, Barros,Luísa, Gonçalo,Margarida
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Dermatologia 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600018
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spelling oai:scielo:S0365-059620120006000182012-11-27Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibioticsAndrade,PedroBarros,LuísaGonçalo,Margarida Diabetes mellitus, type 2 Drug hypersensitivity Insulin Penicillins Insulin, a crucial therapeutic agent for diabetes mellitus, has been rarely associated with hypersensitivity events. We present a 69-year-old type-2 diabetic patient with urticariform lesions on the sites of subcutaneous injection of insulin. The patient denied any known allergies, except for an unspecific cutaneous reaction after intramuscular penicillin administration in childhood. Prick tests revealed positive reactions to all tested human insulins and insulin analogues. Serum IgE levels were above normal range and RAST tests were positive for human, bovine and porcine insulins, as well as beta-lactams. Type 1 IgEmediated allergy to insulin analogues demands a prompt diagnosis and represents a significant therapeutic challenge in diabetic patients.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.87 n.6 20122012-12-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600018en10.1590/S0365-05962012000600018
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Andrade,Pedro
Barros,Luísa
Gonçalo,Margarida
spellingShingle Andrade,Pedro
Barros,Luísa
Gonçalo,Margarida
Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
author_facet Andrade,Pedro
Barros,Luísa
Gonçalo,Margarida
author_sort Andrade,Pedro
title Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
title_short Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
title_full Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
title_fullStr Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
title_full_unstemmed Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
title_sort type 1 ig-e mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics
description Insulin, a crucial therapeutic agent for diabetes mellitus, has been rarely associated with hypersensitivity events. We present a 69-year-old type-2 diabetic patient with urticariform lesions on the sites of subcutaneous injection of insulin. The patient denied any known allergies, except for an unspecific cutaneous reaction after intramuscular penicillin administration in childhood. Prick tests revealed positive reactions to all tested human insulins and insulin analogues. Serum IgE levels were above normal range and RAST tests were positive for human, bovine and porcine insulins, as well as beta-lactams. Type 1 IgEmediated allergy to insulin analogues demands a prompt diagnosis and represents a significant therapeutic challenge in diabetic patients.
publisher Sociedade Brasileira de Dermatologia
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600018
work_keys_str_mv AT andradepedro type1igemediatedallergytohumaninsulininsulinanaloguesandbetalactamantibiotics
AT barrosluisa type1igemediatedallergytohumaninsulininsulinanaloguesandbetalactamantibiotics
AT goncalomargarida type1igemediatedallergytohumaninsulininsulinanaloguesandbetalactamantibiotics
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