Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects
Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients.
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Sociedade Brasileira de Dermatologia
2012
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oai:scielo:S0365-059620120001000132012-04-02Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspectsVieira,Renata Aparecida Martinez Antunes RibeiroMinicucci,Eliana MariaMarques,Mariangela Esther AlencarMarques,Silvio Alencar Carcinoma squamous cell Cheilitis Cyclin-dependent kinase inhibitor proteins Cyclin D1 Protooncogene proteins c-bcl-2 Tumor suppressor protein p53 Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.87 n.1 20122012-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000100013en10.1590/S0365-05962012000100013 |
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English |
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Digital |
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Vieira,Renata Aparecida Martinez Antunes Ribeiro Minicucci,Eliana Maria Marques,Mariangela Esther Alencar Marques,Silvio Alencar |
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Vieira,Renata Aparecida Martinez Antunes Ribeiro Minicucci,Eliana Maria Marques,Mariangela Esther Alencar Marques,Silvio Alencar Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| author_facet |
Vieira,Renata Aparecida Martinez Antunes Ribeiro Minicucci,Eliana Maria Marques,Mariangela Esther Alencar Marques,Silvio Alencar |
| author_sort |
Vieira,Renata Aparecida Martinez Antunes Ribeiro |
| title |
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| title_short |
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| title_full |
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| title_fullStr |
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| title_full_unstemmed |
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| title_sort |
actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects |
| description |
Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients. |
| publisher |
Sociedade Brasileira de Dermatologia |
| publishDate |
2012 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000100013 |
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| _version_ |
1756412401714987008 |