Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide
Abstract Introduction: teduglutide (TED) is indicated for the treatment of patients with short-bowel syndrome (SBS) who are dependent on parenteral support. Case report: we report the case of a 60-year-old woman with SBS treated with TED. She had previously undergone multiple surgical resections due to Crohn's disease. Her remnant bowel included only the duodenum and 50-60 centimeters of jejunum. The patient was dependent on intravenous fluids (2,320 mL/48 h) and had a high stoma output (3,000 mL/day). After four months of TED the jejunostomy output had decreased to 2,200 mL/day with a thicker consistency, and intravenous fluid therapy was reduced to 2,010 mL/48 h. TED was withdrawn due to acute pancreatitis and enlargement of two supraumbilical hernias with high strangulation risk. Discussion: pancreatitis has been reported in clinical studies, and determination of amylase and lipase is recommended in all patients receiving TED. In contrast, there are no recommendations for the surveillance of hernia enlargement in patients on TED therapy, but we suggest the need for surveillance based on this case report.
Main Authors: | , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Grupo Arán
2022
|
Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112022000100027 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0212-16112022000100027 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0212-161120220001000272022-03-30Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutideConejo,IreneMas-Malagarriga,NúriaRiera,PauCardenete,JoanaPuig-Piña,RocíoRodríguez,ManuelPourcq,Jan T de Teduglutide Short bowel syndrome Pancreatitis Hernia enlargement Case report Abstract Introduction: teduglutide (TED) is indicated for the treatment of patients with short-bowel syndrome (SBS) who are dependent on parenteral support. Case report: we report the case of a 60-year-old woman with SBS treated with TED. She had previously undergone multiple surgical resections due to Crohn's disease. Her remnant bowel included only the duodenum and 50-60 centimeters of jejunum. The patient was dependent on intravenous fluids (2,320 mL/48 h) and had a high stoma output (3,000 mL/day). After four months of TED the jejunostomy output had decreased to 2,200 mL/day with a thicker consistency, and intravenous fluid therapy was reduced to 2,010 mL/48 h. TED was withdrawn due to acute pancreatitis and enlargement of two supraumbilical hernias with high strangulation risk. Discussion: pancreatitis has been reported in clinical studies, and determination of amylase and lipase is recommended in all patients receiving TED. In contrast, there are no recommendations for the surveillance of hernia enlargement in patients on TED therapy, but we suggest the need for surveillance based on this case report.Grupo AránNutrición Hospitalaria v.39 n.1 20222022-02-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112022000100027en |
institution |
SCIELO |
collection |
OJS |
country |
España |
countrycode |
ES |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-es |
tag |
revista |
region |
Europa del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Conejo,Irene Mas-Malagarriga,Núria Riera,Pau Cardenete,Joana Puig-Piña,Rocío Rodríguez,Manuel Pourcq,Jan T de |
spellingShingle |
Conejo,Irene Mas-Malagarriga,Núria Riera,Pau Cardenete,Joana Puig-Piña,Rocío Rodríguez,Manuel Pourcq,Jan T de Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
author_facet |
Conejo,Irene Mas-Malagarriga,Núria Riera,Pau Cardenete,Joana Puig-Piña,Rocío Rodríguez,Manuel Pourcq,Jan T de |
author_sort |
Conejo,Irene |
title |
Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
title_short |
Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
title_full |
Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
title_fullStr |
Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
title_full_unstemmed |
Hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
title_sort |
hernia enlargement and pancreatitis in a patient with short bowel syndrome treated with teduglutide |
description |
Abstract Introduction: teduglutide (TED) is indicated for the treatment of patients with short-bowel syndrome (SBS) who are dependent on parenteral support. Case report: we report the case of a 60-year-old woman with SBS treated with TED. She had previously undergone multiple surgical resections due to Crohn's disease. Her remnant bowel included only the duodenum and 50-60 centimeters of jejunum. The patient was dependent on intravenous fluids (2,320 mL/48 h) and had a high stoma output (3,000 mL/day). After four months of TED the jejunostomy output had decreased to 2,200 mL/day with a thicker consistency, and intravenous fluid therapy was reduced to 2,010 mL/48 h. TED was withdrawn due to acute pancreatitis and enlargement of two supraumbilical hernias with high strangulation risk. Discussion: pancreatitis has been reported in clinical studies, and determination of amylase and lipase is recommended in all patients receiving TED. In contrast, there are no recommendations for the surveillance of hernia enlargement in patients on TED therapy, but we suggest the need for surveillance based on this case report. |
publisher |
Grupo Arán |
publishDate |
2022 |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112022000100027 |
work_keys_str_mv |
AT conejoirene herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT masmalagarriganuria herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT rierapau herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT cardenetejoana herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT puigpinarocio herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT rodriguezmanuel herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide AT pourcqjantde herniaenlargementandpancreatitisinapatientwithshortbowelsyndrometreatedwithteduglutide |
_version_ |
1755937099729600512 |