Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease
Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. Objectives: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism. Material and methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed. Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (p = 0.001), myristic acid (p = 0.036), stearic acid (p = 0.031), and total saturated fatty acids (SFAs) (p = 0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (p = 0.022), erucic acid (p = 0.002), total monounsaturated fatty acids (MUFAs) (p = 0.039) and oleic acid/stearic acid ratio (p = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (p = 0.977). The age at first full pregnancy (p = 0.004) was significantly associated with the development BC, whereas BMI (p = 0.005); percentage of body fat (p = 0.024); physical activity (p = 0.036); and age at menarche (p = 0.008), at first full pregnancy (p < 0.001), and of first mammogram (p = 0.018) were significantly associated with the development of BBD. Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.
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2016
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oai:scielo:S0212-161120160006000162017-03-28Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast diseaseLopes da Conceição,LisianeMoura e Dias,Mariana dePessoa,Milene CristineGraças Pena,Geórgia dasSantos Mendes,Maria CarolinaVilas Boas Neves,CristianeMiranda Hermsdorff,Helen HermanaNascimento de Freitas,RenataGouveia Peluzio,Maria do Carmo Fatty acids Breast cancer Benign breast disease PPARγ Dietary intake Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. Objectives: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism. Material and methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed. Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (p = 0.001), myristic acid (p = 0.036), stearic acid (p = 0.031), and total saturated fatty acids (SFAs) (p = 0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (p = 0.022), erucic acid (p = 0.002), total monounsaturated fatty acids (MUFAs) (p = 0.039) and oleic acid/stearic acid ratio (p = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (p = 0.977). The age at first full pregnancy (p = 0.004) was significantly associated with the development BC, whereas BMI (p = 0.005); percentage of body fat (p = 0.024); physical activity (p = 0.036); and age at menarche (p = 0.008), at first full pregnancy (p < 0.001), and of first mammogram (p = 0.018) were significantly associated with the development of BBD. Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.Grupo AránNutrición Hospitalaria v.33 n.6 20162016-12-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000600016en |
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Lopes da Conceição,Lisiane Moura e Dias,Mariana de Pessoa,Milene Cristine Graças Pena,Geórgia das Santos Mendes,Maria Carolina Vilas Boas Neves,Cristiane Miranda Hermsdorff,Helen Hermana Nascimento de Freitas,Renata Gouveia Peluzio,Maria do Carmo |
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Lopes da Conceição,Lisiane Moura e Dias,Mariana de Pessoa,Milene Cristine Graças Pena,Geórgia das Santos Mendes,Maria Carolina Vilas Boas Neves,Cristiane Miranda Hermsdorff,Helen Hermana Nascimento de Freitas,Renata Gouveia Peluzio,Maria do Carmo Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
author_facet |
Lopes da Conceição,Lisiane Moura e Dias,Mariana de Pessoa,Milene Cristine Graças Pena,Geórgia das Santos Mendes,Maria Carolina Vilas Boas Neves,Cristiane Miranda Hermsdorff,Helen Hermana Nascimento de Freitas,Renata Gouveia Peluzio,Maria do Carmo |
author_sort |
Lopes da Conceição,Lisiane |
title |
Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
title_short |
Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
title_full |
Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
title_fullStr |
Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
title_full_unstemmed |
Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
title_sort |
difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease |
description |
Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. Objectives: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism. Material and methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed. Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (p = 0.001), myristic acid (p = 0.036), stearic acid (p = 0.031), and total saturated fatty acids (SFAs) (p = 0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (p = 0.022), erucic acid (p = 0.002), total monounsaturated fatty acids (MUFAs) (p = 0.039) and oleic acid/stearic acid ratio (p = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (p = 0.977). The age at first full pregnancy (p = 0.004) was significantly associated with the development BC, whereas BMI (p = 0.005); percentage of body fat (p = 0.024); physical activity (p = 0.036); and age at menarche (p = 0.008), at first full pregnancy (p < 0.001), and of first mammogram (p = 0.018) were significantly associated with the development of BBD. Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC. |
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Grupo Arán |
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2016 |
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http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000600016 |
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