Serum uric acid can predict higher C-reactive protein levels in apparently healthy men
Introduction: Epidemiological studies have shown an association between coronary heart disease and emerging cardiovascular risk factors, such as, levels of fibrinogen and high-sensitivity C-reactive protein (hs-CRP). Objectives: To verify the ability of biochemical indicators in discriminating changes in the levels of hs-CRP and fibrinogen, in apparently healthy adult men. Methods: Were evaluated 130 apparently healthy men (20-59 years), having measurement of weight and height. Biochemical measurements (lipid profile, fasting glucose, uric acid, hs-CRP and fibrinogen) were performed. Body mass index, total cholesterol/HDL-c and LDL-c/HDL-c ratios were calculated. It was considered as the cutoff point for hs-CRP values > 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample. Results: The uric acid showed the best correlation (r = 0.325) and the higher area under the ROC curve (0.704 ± 0.054), showing greater ability to discriminate higher levels of hs-CRP (p < 0.01). The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 ± 0.049 and 0.624 ± 0.049) in identify higher levels of fibrinogen (p < 0.05). Conclusion: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. It was suggested the use of biochemical markers in the clinical practice, in order to establish preventive action for cardiovascular disease in apparently healthy adult men.
| Main Authors: | , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Grupo Arán
2014
|
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000400030 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0212-16112014000400030 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0212-161120140004000302015-07-31Serum uric acid can predict higher C-reactive protein levels in apparently healthy menCarvalho Vidigal,Fernanda deFrandsen Paez de Lima Rosado,Lina EnriquetaPaixão Rosado,GilbertoCassia Lanes Ribeiro,Rita deCarmo Castro Franceschini,Sylvia do Lipoproteins Uric Acid Fibrinogen C-reactive protein Inflammation Introduction: Epidemiological studies have shown an association between coronary heart disease and emerging cardiovascular risk factors, such as, levels of fibrinogen and high-sensitivity C-reactive protein (hs-CRP). Objectives: To verify the ability of biochemical indicators in discriminating changes in the levels of hs-CRP and fibrinogen, in apparently healthy adult men. Methods: Were evaluated 130 apparently healthy men (20-59 years), having measurement of weight and height. Biochemical measurements (lipid profile, fasting glucose, uric acid, hs-CRP and fibrinogen) were performed. Body mass index, total cholesterol/HDL-c and LDL-c/HDL-c ratios were calculated. It was considered as the cutoff point for hs-CRP values > 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample. Results: The uric acid showed the best correlation (r = 0.325) and the higher area under the ROC curve (0.704 ± 0.054), showing greater ability to discriminate higher levels of hs-CRP (p < 0.01). The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 ± 0.049 and 0.624 ± 0.049) in identify higher levels of fibrinogen (p < 0.05). Conclusion: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. It was suggested the use of biochemical markers in the clinical practice, in order to establish preventive action for cardiovascular disease in apparently healthy adult men.Grupo AránNutrición Hospitalaria v.29 n.4 20142014-04-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000400030en |
| institution |
SCIELO |
| collection |
OJS |
| country |
España |
| countrycode |
ES |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-es |
| tag |
revista |
| region |
Europa del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Carvalho Vidigal,Fernanda de Frandsen Paez de Lima Rosado,Lina Enriqueta Paixão Rosado,Gilberto Cassia Lanes Ribeiro,Rita de Carmo Castro Franceschini,Sylvia do |
| spellingShingle |
Carvalho Vidigal,Fernanda de Frandsen Paez de Lima Rosado,Lina Enriqueta Paixão Rosado,Gilberto Cassia Lanes Ribeiro,Rita de Carmo Castro Franceschini,Sylvia do Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| author_facet |
Carvalho Vidigal,Fernanda de Frandsen Paez de Lima Rosado,Lina Enriqueta Paixão Rosado,Gilberto Cassia Lanes Ribeiro,Rita de Carmo Castro Franceschini,Sylvia do |
| author_sort |
Carvalho Vidigal,Fernanda de |
| title |
Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| title_short |
Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| title_full |
Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| title_fullStr |
Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| title_full_unstemmed |
Serum uric acid can predict higher C-reactive protein levels in apparently healthy men |
| title_sort |
serum uric acid can predict higher c-reactive protein levels in apparently healthy men |
| description |
Introduction: Epidemiological studies have shown an association between coronary heart disease and emerging cardiovascular risk factors, such as, levels of fibrinogen and high-sensitivity C-reactive protein (hs-CRP). Objectives: To verify the ability of biochemical indicators in discriminating changes in the levels of hs-CRP and fibrinogen, in apparently healthy adult men. Methods: Were evaluated 130 apparently healthy men (20-59 years), having measurement of weight and height. Biochemical measurements (lipid profile, fasting glucose, uric acid, hs-CRP and fibrinogen) were performed. Body mass index, total cholesterol/HDL-c and LDL-c/HDL-c ratios were calculated. It was considered as the cutoff point for hs-CRP values > 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample. Results: The uric acid showed the best correlation (r = 0.325) and the higher area under the ROC curve (0.704 ± 0.054), showing greater ability to discriminate higher levels of hs-CRP (p < 0.01). The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 ± 0.049 and 0.624 ± 0.049) in identify higher levels of fibrinogen (p < 0.05). Conclusion: The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. It was suggested the use of biochemical markers in the clinical practice, in order to establish preventive action for cardiovascular disease in apparently healthy adult men. |
| publisher |
Grupo Arán |
| publishDate |
2014 |
| url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000400030 |
| work_keys_str_mv |
AT carvalhovidigalfernandade serumuricacidcanpredicthighercreactiveproteinlevelsinapparentlyhealthymen AT frandsenpaezdelimarosadolinaenriqueta serumuricacidcanpredicthighercreactiveproteinlevelsinapparentlyhealthymen AT paixaorosadogilberto serumuricacidcanpredicthighercreactiveproteinlevelsinapparentlyhealthymen AT cassialanesribeiroritade serumuricacidcanpredicthighercreactiveproteinlevelsinapparentlyhealthymen AT carmocastrofranceschinisylviado serumuricacidcanpredicthighercreactiveproteinlevelsinapparentlyhealthymen |
| _version_ |
1755936768199229440 |