Anti-inflammatory properties of dietary flavonoids
Flavonoids are a group of natural substances that are located in sources of vegetal origin. More than 4,000 varieties of flavonoids have been identified. All of them are phenyl-benzopyrones of low molecular weight with a basic structure formed by two benzene rings united through a heterocyclic pyrane or pyrone. Besides their relevance in plants, flavonoids are important for human health. Their antioxidant capacity confers a therapeutic potential in cardiovascular diseases, gastric or duodenal ulcers, cancer or hepatic pathologies. Also important are their antiviral and anti-allergic actions, as well as their anti-thrombotic and anti-inflammatory properties. Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators. It has been demonstrated that flavonoids are able to inhibit both enzymes, as well as other mediators of the inflammatory process such as reactive C protein or adhesion molecules. Modulation of the cascade of molecular events leading to the overexpression of those mediators include inhibition of transcription factors such as nuclear factor kappa B and AP-1, through the inhibition of protein kinases involved in signal transduction. Increased antioxidant defenses through activation of the NF-E2 related factor 2 (Nrf2) also contribute to the anti-inflammatory capacity of flavonoids
Main Authors: | , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Grupo Arán
2007
|
Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000400002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0212-16112007000400002 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0212-161120070004000022008-09-25Anti-inflammatory properties of dietary flavonoidsGonzález-Gallego,J.Sánchez-Campos,S.Tuñón,M. J. Flavonoids Inflammation Oxidative stress Nuclear factor kappa B Nitric oxide Flavonoids are a group of natural substances that are located in sources of vegetal origin. More than 4,000 varieties of flavonoids have been identified. All of them are phenyl-benzopyrones of low molecular weight with a basic structure formed by two benzene rings united through a heterocyclic pyrane or pyrone. Besides their relevance in plants, flavonoids are important for human health. Their antioxidant capacity confers a therapeutic potential in cardiovascular diseases, gastric or duodenal ulcers, cancer or hepatic pathologies. Also important are their antiviral and anti-allergic actions, as well as their anti-thrombotic and anti-inflammatory properties. Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators. It has been demonstrated that flavonoids are able to inhibit both enzymes, as well as other mediators of the inflammatory process such as reactive C protein or adhesion molecules. Modulation of the cascade of molecular events leading to the overexpression of those mediators include inhibition of transcription factors such as nuclear factor kappa B and AP-1, through the inhibition of protein kinases involved in signal transduction. Increased antioxidant defenses through activation of the NF-E2 related factor 2 (Nrf2) also contribute to the anti-inflammatory capacity of flavonoidsGrupo AránNutrición Hospitalaria v.22 n.3 20072007-06-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000400002en |
institution |
SCIELO |
collection |
OJS |
country |
España |
countrycode |
ES |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-es |
tag |
revista |
region |
Europa del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
González-Gallego,J. Sánchez-Campos,S. Tuñón,M. J. |
spellingShingle |
González-Gallego,J. Sánchez-Campos,S. Tuñón,M. J. Anti-inflammatory properties of dietary flavonoids |
author_facet |
González-Gallego,J. Sánchez-Campos,S. Tuñón,M. J. |
author_sort |
González-Gallego,J. |
title |
Anti-inflammatory properties of dietary flavonoids |
title_short |
Anti-inflammatory properties of dietary flavonoids |
title_full |
Anti-inflammatory properties of dietary flavonoids |
title_fullStr |
Anti-inflammatory properties of dietary flavonoids |
title_full_unstemmed |
Anti-inflammatory properties of dietary flavonoids |
title_sort |
anti-inflammatory properties of dietary flavonoids |
description |
Flavonoids are a group of natural substances that are located in sources of vegetal origin. More than 4,000 varieties of flavonoids have been identified. All of them are phenyl-benzopyrones of low molecular weight with a basic structure formed by two benzene rings united through a heterocyclic pyrane or pyrone. Besides their relevance in plants, flavonoids are important for human health. Their antioxidant capacity confers a therapeutic potential in cardiovascular diseases, gastric or duodenal ulcers, cancer or hepatic pathologies. Also important are their antiviral and anti-allergic actions, as well as their anti-thrombotic and anti-inflammatory properties. Prostaglandins and nitric oxide biosynthesis is involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of these mediators. It has been demonstrated that flavonoids are able to inhibit both enzymes, as well as other mediators of the inflammatory process such as reactive C protein or adhesion molecules. Modulation of the cascade of molecular events leading to the overexpression of those mediators include inhibition of transcription factors such as nuclear factor kappa B and AP-1, through the inhibition of protein kinases involved in signal transduction. Increased antioxidant defenses through activation of the NF-E2 related factor 2 (Nrf2) also contribute to the anti-inflammatory capacity of flavonoids |
publisher |
Grupo Arán |
publishDate |
2007 |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000400002 |
work_keys_str_mv |
AT gonzalezgallegoj antiinflammatorypropertiesofdietaryflavonoids AT sanchezcamposs antiinflammatorypropertiesofdietaryflavonoids AT tunonmj antiinflammatorypropertiesofdietaryflavonoids |
_version_ |
1755936554265608192 |