Continuous clonidine infusion: an alternative for children on mechanical ventilation

SUMMARY OBJECTIVE: This study aimed to assess the clonidine infusion rate in the first 6 h, as maintenance dose (first 24 h), and in the pre-extubation period (last 24 h), as well as the cumulative dose of other sedatives and the hemodynamic response. METHODS: This is a retrospective cohort study. RESULTS: Children up to the age of 2 years who were admitted to the pediatric intensive care unit of a tertiary referral hospital in the south region of Brazil, between January 2017 and December 2018, were submitted to mechanical ventilation, and received continuous clonidine infusions were included in the study. The initial, maintenance, and pre-extubation doses of clonidine; the vasoactive-inotropic score; heart rate; and systolic and diastolic blood pressure of the study participants were assessed. A total of 66 patients with a median age of 4 months who were receiving clonidine infusions were included. The main indications for mechanical ventilation were acute viral bronchiolitis (56%) and pneumonia associated with acute respiratory distress syndrome (15%). The median of clonidine infusion in the first 6 h (66 patients) was 0.53 μg/kg/h (IQR 0.49–0.88), followed by 0.85 μg/kg/h (IQR 0.53–1.03) during maintenance (57 patients) and 0.63 μg/kg/h (IQR 0.54–1.01) during extubation period (42 patients) (p=0.03). No differences were observed in the doses regarding the indication for mechanical ventilation. Clonidine infusion was not associated with hemodynamic changes and showed no differences when associated with adjuvants. CONCLUSION: Clonidine demonstrated to be a well-tolerated sedation option in pediatric patients submitted to mechanical ventilation, without relevant influence in hemodynamic variables.

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Main Authors: Neves,Cinara Carneiro, Fiamenghi,Verônica Indicatti, Fontela,Patricia Scolari, Piva,Jefferson Pedro
Format: Digital revista
Language:English
Published: Associação Médica Brasileira 2022
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022000700953
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spelling oai:scielo:S0104-423020220007009532022-10-17Continuous clonidine infusion: an alternative for children on mechanical ventilationNeves,Cinara CarneiroFiamenghi,Verônica IndicattiFontela,Patricia ScolariPiva,Jefferson Pedro Clonidine Pediatric intensive care unit Artificial respiration Sedation, conscious Analgesia SUMMARY OBJECTIVE: This study aimed to assess the clonidine infusion rate in the first 6 h, as maintenance dose (first 24 h), and in the pre-extubation period (last 24 h), as well as the cumulative dose of other sedatives and the hemodynamic response. METHODS: This is a retrospective cohort study. RESULTS: Children up to the age of 2 years who were admitted to the pediatric intensive care unit of a tertiary referral hospital in the south region of Brazil, between January 2017 and December 2018, were submitted to mechanical ventilation, and received continuous clonidine infusions were included in the study. The initial, maintenance, and pre-extubation doses of clonidine; the vasoactive-inotropic score; heart rate; and systolic and diastolic blood pressure of the study participants were assessed. A total of 66 patients with a median age of 4 months who were receiving clonidine infusions were included. The main indications for mechanical ventilation were acute viral bronchiolitis (56%) and pneumonia associated with acute respiratory distress syndrome (15%). The median of clonidine infusion in the first 6 h (66 patients) was 0.53 μg/kg/h (IQR 0.49–0.88), followed by 0.85 μg/kg/h (IQR 0.53–1.03) during maintenance (57 patients) and 0.63 μg/kg/h (IQR 0.54–1.01) during extubation period (42 patients) (p=0.03). No differences were observed in the doses regarding the indication for mechanical ventilation. Clonidine infusion was not associated with hemodynamic changes and showed no differences when associated with adjuvants. CONCLUSION: Clonidine demonstrated to be a well-tolerated sedation option in pediatric patients submitted to mechanical ventilation, without relevant influence in hemodynamic variables.info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.68 n.7 20222022-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022000700953en10.1590/1806-9282.20220166
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country Brasil
countrycode BR
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libraryname SciELO
language English
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author Neves,Cinara Carneiro
Fiamenghi,Verônica Indicatti
Fontela,Patricia Scolari
Piva,Jefferson Pedro
spellingShingle Neves,Cinara Carneiro
Fiamenghi,Verônica Indicatti
Fontela,Patricia Scolari
Piva,Jefferson Pedro
Continuous clonidine infusion: an alternative for children on mechanical ventilation
author_facet Neves,Cinara Carneiro
Fiamenghi,Verônica Indicatti
Fontela,Patricia Scolari
Piva,Jefferson Pedro
author_sort Neves,Cinara Carneiro
title Continuous clonidine infusion: an alternative for children on mechanical ventilation
title_short Continuous clonidine infusion: an alternative for children on mechanical ventilation
title_full Continuous clonidine infusion: an alternative for children on mechanical ventilation
title_fullStr Continuous clonidine infusion: an alternative for children on mechanical ventilation
title_full_unstemmed Continuous clonidine infusion: an alternative for children on mechanical ventilation
title_sort continuous clonidine infusion: an alternative for children on mechanical ventilation
description SUMMARY OBJECTIVE: This study aimed to assess the clonidine infusion rate in the first 6 h, as maintenance dose (first 24 h), and in the pre-extubation period (last 24 h), as well as the cumulative dose of other sedatives and the hemodynamic response. METHODS: This is a retrospective cohort study. RESULTS: Children up to the age of 2 years who were admitted to the pediatric intensive care unit of a tertiary referral hospital in the south region of Brazil, between January 2017 and December 2018, were submitted to mechanical ventilation, and received continuous clonidine infusions were included in the study. The initial, maintenance, and pre-extubation doses of clonidine; the vasoactive-inotropic score; heart rate; and systolic and diastolic blood pressure of the study participants were assessed. A total of 66 patients with a median age of 4 months who were receiving clonidine infusions were included. The main indications for mechanical ventilation were acute viral bronchiolitis (56%) and pneumonia associated with acute respiratory distress syndrome (15%). The median of clonidine infusion in the first 6 h (66 patients) was 0.53 μg/kg/h (IQR 0.49–0.88), followed by 0.85 μg/kg/h (IQR 0.53–1.03) during maintenance (57 patients) and 0.63 μg/kg/h (IQR 0.54–1.01) during extubation period (42 patients) (p=0.03). No differences were observed in the doses regarding the indication for mechanical ventilation. Clonidine infusion was not associated with hemodynamic changes and showed no differences when associated with adjuvants. CONCLUSION: Clonidine demonstrated to be a well-tolerated sedation option in pediatric patients submitted to mechanical ventilation, without relevant influence in hemodynamic variables.
publisher Associação Médica Brasileira
publishDate 2022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302022000700953
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