Ototoxic effects of hydroxychloroquine
SUMMARY OBJECTIVE To present scientific evidence based on a systematic review of the literature (PRISMA), aiming to systematize evidence of the ototoxic effects of hydroxychloroquine (HCQ). METHODS The studies were selected using a combination based on the Medical Subject Headings (MeSH). The databases searched were MEDLINE (PubMed), LILACS, SciELO, and BIREME, encompassing articles from January 2010 to May 2020, with no restrictions of language and place of publication. RESULTS A total of 148 articles with the potential to be included were retrieved. Of these, two answered the research question, which consisted of seeking evidence of the ototoxic effects of hydroxychloroquine. These studies scored 11 in their quality assessment with the modified protocol by Pithon et al.13. CONCLUSIONS The studies reported possible ototoxicity of HCQ. Audiovestibular changes, such as hearing loss, peripheral vestibular syndrome, and tinnitus were evidenced in patients submitted to HCQ. The improvement in the audiological examinations and the regression in the vestibular syndrome after stopping the treatment with HCQ are strong arguments in favor of the ototoxicity caused by this medication. However, there are still divergences about the relationship between ototoxic effects and the use of HCQ.
Main Authors: | Gonçalves,Laura Faustino, Patatt,Fernanda Soares Aurélio, de Paiva,Karina Mary, Haas,Patrícia |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Médica Brasileira
2021
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000200108 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Ototoxic effects of antineoplastic drugs: a systematic review
by: Patatt,Fernanda Soares Aurélio, et al.
Published: (2022) -
The Ototoxicity of Chloroquine and Hydroxychloroquine: A Systematic Review
by: Fernandes,Carolina Pereira, et al.
Published: (2022) -
Hydroxychloroquine ototoxicity in a patient with systemic lupus erythematosus
by: Fernandes,Mariana Rita de Novaes, et al.
Published: (2018) -
Association between autism spectrum disorder and changes in the central auditory processing in children
by: Gonçalves,Laura Faustino, et al.
Published: (2021) -
Kawasaki and COVID-19 disease in children: a systematic review
by: Gonçalves,Laura Faustino, et al.
Published: (2020)