Melatonin and organ transplantation: what is the relationship?
SUMMARY Melatonin has anti-inflammatory and antioxidant properties that can influence tissue growth and apoptosis. This aspect may influence the success of organ transplantation. OBJECTIVE To evaluate the relationship between melatonin and organ transplantation. METHODS A systematic review was performed in PubMed databases using the search terms: “melatonin physiology” or “melatonin therapy” and “transplant pharmacology” or “transplant physiology” or “transplant therapy” or “Transplant therapy”. Experiments on the organs of the reproductive system were not included. After analysis, five articles were selected after reading the title and abstract of 50 manuscripts. The works were divided into two aspects: a) analysis of the influence of the organ transplantation procedure on melatonin production; b) action of melatonin on organ transplantation. RESULTS The cardiac transplantation surgical procedure, immunosuppression, and graft did not influence melatonin secretion in rodents, but there was a significant reduction of melatonin in the renal transplantation procedure in patients with renal insufficiency. Melatonin administration in experimental models decreased rejection and improved transplant success. CONCLUSION Studies show that melatonin can reduce organ and species dependence, and the use of melatonin decreases graft rejection.
Main Authors: | , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Médica Brasileira
2020
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000300353 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0104-42302020000300353 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0104-423020200003003532020-05-29Melatonin and organ transplantation: what is the relationship?Haddad,Carolina F.Haddad,Jorge M.Veiga,Eduardo Carvalho de ArrudaSorpreso,Isabel Cristina EspositoSimões,Ricardo SantosBaracat,Edmund ChadaSoares Júnior,José Maria Melatonin Oxidative stress Transplants SUMMARY Melatonin has anti-inflammatory and antioxidant properties that can influence tissue growth and apoptosis. This aspect may influence the success of organ transplantation. OBJECTIVE To evaluate the relationship between melatonin and organ transplantation. METHODS A systematic review was performed in PubMed databases using the search terms: “melatonin physiology” or “melatonin therapy” and “transplant pharmacology” or “transplant physiology” or “transplant therapy” or “Transplant therapy”. Experiments on the organs of the reproductive system were not included. After analysis, five articles were selected after reading the title and abstract of 50 manuscripts. The works were divided into two aspects: a) analysis of the influence of the organ transplantation procedure on melatonin production; b) action of melatonin on organ transplantation. RESULTS The cardiac transplantation surgical procedure, immunosuppression, and graft did not influence melatonin secretion in rodents, but there was a significant reduction of melatonin in the renal transplantation procedure in patients with renal insufficiency. Melatonin administration in experimental models decreased rejection and improved transplant success. CONCLUSION Studies show that melatonin can reduce organ and species dependence, and the use of melatonin decreases graft rejection.info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.66 n.3 20202020-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000300353en10.1590/1806-9282.66.3.353 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Haddad,Carolina F. Haddad,Jorge M. Veiga,Eduardo Carvalho de Arruda Sorpreso,Isabel Cristina Esposito Simões,Ricardo Santos Baracat,Edmund Chada Soares Júnior,José Maria |
spellingShingle |
Haddad,Carolina F. Haddad,Jorge M. Veiga,Eduardo Carvalho de Arruda Sorpreso,Isabel Cristina Esposito Simões,Ricardo Santos Baracat,Edmund Chada Soares Júnior,José Maria Melatonin and organ transplantation: what is the relationship? |
author_facet |
Haddad,Carolina F. Haddad,Jorge M. Veiga,Eduardo Carvalho de Arruda Sorpreso,Isabel Cristina Esposito Simões,Ricardo Santos Baracat,Edmund Chada Soares Júnior,José Maria |
author_sort |
Haddad,Carolina F. |
title |
Melatonin and organ transplantation: what is the relationship? |
title_short |
Melatonin and organ transplantation: what is the relationship? |
title_full |
Melatonin and organ transplantation: what is the relationship? |
title_fullStr |
Melatonin and organ transplantation: what is the relationship? |
title_full_unstemmed |
Melatonin and organ transplantation: what is the relationship? |
title_sort |
melatonin and organ transplantation: what is the relationship? |
description |
SUMMARY Melatonin has anti-inflammatory and antioxidant properties that can influence tissue growth and apoptosis. This aspect may influence the success of organ transplantation. OBJECTIVE To evaluate the relationship between melatonin and organ transplantation. METHODS A systematic review was performed in PubMed databases using the search terms: “melatonin physiology” or “melatonin therapy” and “transplant pharmacology” or “transplant physiology” or “transplant therapy” or “Transplant therapy”. Experiments on the organs of the reproductive system were not included. After analysis, five articles were selected after reading the title and abstract of 50 manuscripts. The works were divided into two aspects: a) analysis of the influence of the organ transplantation procedure on melatonin production; b) action of melatonin on organ transplantation. RESULTS The cardiac transplantation surgical procedure, immunosuppression, and graft did not influence melatonin secretion in rodents, but there was a significant reduction of melatonin in the renal transplantation procedure in patients with renal insufficiency. Melatonin administration in experimental models decreased rejection and improved transplant success. CONCLUSION Studies show that melatonin can reduce organ and species dependence, and the use of melatonin decreases graft rejection. |
publisher |
Associação Médica Brasileira |
publishDate |
2020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000300353 |
work_keys_str_mv |
AT haddadcarolinaf melatoninandorgantransplantationwhatistherelationship AT haddadjorgem melatoninandorgantransplantationwhatistherelationship AT veigaeduardocarvalhodearruda melatoninandorgantransplantationwhatistherelationship AT sorpresoisabelcristinaesposito melatoninandorgantransplantationwhatistherelationship AT simoesricardosantos melatoninandorgantransplantationwhatistherelationship AT baracatedmundchada melatoninandorgantransplantationwhatistherelationship AT soaresjuniorjosemaria melatoninandorgantransplantationwhatistherelationship |
_version_ |
1756410055551352832 |