Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient
SUMMARY We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). The patient underwent an open biopsy and resection, and the diagnosis of diffuse large B-cell lymphoma (DLBCL) was established. The patient received intravenous dexamethasone with symptoms remission, followed by four cycles of methotrexate plus cytarabine. After 3 months, the patient returned with decreased consciences level and a new MRI revealed a right superior frontal gyrus lesion with features suggesting a lymphomatous lesion. The patient died five days after her relapse.
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Associação Médica Brasileira
2019
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oai:scielo:S0104-423020190002001362019-03-15Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patientBeraldo,Gabriel LaverdiBrito,Angelo Borsarelli CarvalhoDelamain,Márcia TorresanSouza,Carmino Antonio deLima,Carmen Silvia PassosBonfitto,João Felipe LeiteQueiroz,Luciano de SouzaReis,Fabiano Cerebellum Lymphoma, Large B-Cell, Diffuse Magnetic Resonance Spectroscopy Middle cerebellar peduncle SUMMARY We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). The patient underwent an open biopsy and resection, and the diagnosis of diffuse large B-cell lymphoma (DLBCL) was established. The patient received intravenous dexamethasone with symptoms remission, followed by four cycles of methotrexate plus cytarabine. After 3 months, the patient returned with decreased consciences level and a new MRI revealed a right superior frontal gyrus lesion with features suggesting a lymphomatous lesion. The patient died five days after her relapse.info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.65 n.2 20192019-02-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200136en10.1590/1806-9282.65.2.136 |
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Beraldo,Gabriel Laverdi Brito,Angelo Borsarelli Carvalho Delamain,Márcia Torresan Souza,Carmino Antonio de Lima,Carmen Silvia Passos Bonfitto,João Felipe Leite Queiroz,Luciano de Souza Reis,Fabiano |
| spellingShingle |
Beraldo,Gabriel Laverdi Brito,Angelo Borsarelli Carvalho Delamain,Márcia Torresan Souza,Carmino Antonio de Lima,Carmen Silvia Passos Bonfitto,João Felipe Leite Queiroz,Luciano de Souza Reis,Fabiano Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| author_facet |
Beraldo,Gabriel Laverdi Brito,Angelo Borsarelli Carvalho Delamain,Márcia Torresan Souza,Carmino Antonio de Lima,Carmen Silvia Passos Bonfitto,João Felipe Leite Queiroz,Luciano de Souza Reis,Fabiano |
| author_sort |
Beraldo,Gabriel Laverdi |
| title |
Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| title_short |
Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| title_full |
Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| title_fullStr |
Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| title_full_unstemmed |
Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| title_sort |
primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient |
| description |
SUMMARY We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). The patient underwent an open biopsy and resection, and the diagnosis of diffuse large B-cell lymphoma (DLBCL) was established. The patient received intravenous dexamethasone with symptoms remission, followed by four cycles of methotrexate plus cytarabine. After 3 months, the patient returned with decreased consciences level and a new MRI revealed a right superior frontal gyrus lesion with features suggesting a lymphomatous lesion. The patient died five days after her relapse. |
| publisher |
Associação Médica Brasileira |
| publishDate |
2019 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200136 |
| work_keys_str_mv |
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