Quality of life of patients with rheumatoid arthritis under biological therapy
Summary Objective: assessing health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA), before and after treatment with biological therapy. Methods: a longitudinal study, conducted from November 2010 to September 2011, with implementation of the instruments HAQ II (health assessment questionnaire) and SF-36 (medical outcomes short-from health survey). Barlett test, Anova, Friedman and paired t-test were performed for multiple extracts. Results: 30 patients were evaluated, mean age of 47.6 (SD: 12.25) years and prevalence of females (90%). The mean score of HAQ II before treatment was 1.97, with significant reduction of up to 1.23 after six months of biological therapy (p<0.01). Most of the SF-36 domains showed significant improvement after six months of treatment (p<0.01), highlighting the social aspects, pain, physical functioning, emotional issues, vitality and physical aspects. Conclusion: the use of biologic therapy in patients with RA refractory to standard therapies proved to be an important pharmacological strategy for improving HRQL.
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Associação Médica Brasileira
2015
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oai:scielo:S0104-423020150002001262015-07-27Quality of life of patients with rheumatoid arthritis under biological therapyAzevedo,Amanda Figueiredo BarbosaPetribú,Katia Cristina Lima deLima,Moacir de NovaesSilva,André Santos daRocha Filho,José de ArimateaMariano,Maria Helena Queiroz de AraújoRushansky,Eliézer rheumatoid arthritis biological therapy quality of life rheumatology rheumatic diseases Summary Objective: assessing health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA), before and after treatment with biological therapy. Methods: a longitudinal study, conducted from November 2010 to September 2011, with implementation of the instruments HAQ II (health assessment questionnaire) and SF-36 (medical outcomes short-from health survey). Barlett test, Anova, Friedman and paired t-test were performed for multiple extracts. Results: 30 patients were evaluated, mean age of 47.6 (SD: 12.25) years and prevalence of females (90%). The mean score of HAQ II before treatment was 1.97, with significant reduction of up to 1.23 after six months of biological therapy (p<0.01). Most of the SF-36 domains showed significant improvement after six months of treatment (p<0.01), highlighting the social aspects, pain, physical functioning, emotional issues, vitality and physical aspects. Conclusion: the use of biologic therapy in patients with RA refractory to standard therapies proved to be an important pharmacological strategy for improving HRQL. info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.61 n.2 20152015-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000200126en10.1590/1806-9282.61.02.126 |
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Azevedo,Amanda Figueiredo Barbosa Petribú,Katia Cristina Lima de Lima,Moacir de Novaes Silva,André Santos da Rocha Filho,José de Arimatea Mariano,Maria Helena Queiroz de Araújo Rushansky,Eliézer |
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Azevedo,Amanda Figueiredo Barbosa Petribú,Katia Cristina Lima de Lima,Moacir de Novaes Silva,André Santos da Rocha Filho,José de Arimatea Mariano,Maria Helena Queiroz de Araújo Rushansky,Eliézer Quality of life of patients with rheumatoid arthritis under biological therapy |
author_facet |
Azevedo,Amanda Figueiredo Barbosa Petribú,Katia Cristina Lima de Lima,Moacir de Novaes Silva,André Santos da Rocha Filho,José de Arimatea Mariano,Maria Helena Queiroz de Araújo Rushansky,Eliézer |
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Azevedo,Amanda Figueiredo Barbosa |
title |
Quality of life of patients with rheumatoid arthritis under biological therapy |
title_short |
Quality of life of patients with rheumatoid arthritis under biological therapy |
title_full |
Quality of life of patients with rheumatoid arthritis under biological therapy |
title_fullStr |
Quality of life of patients with rheumatoid arthritis under biological therapy |
title_full_unstemmed |
Quality of life of patients with rheumatoid arthritis under biological therapy |
title_sort |
quality of life of patients with rheumatoid arthritis under biological therapy |
description |
Summary Objective: assessing health-related quality of life (HRQL) in patients with rheumatoid arthritis (RA), before and after treatment with biological therapy. Methods: a longitudinal study, conducted from November 2010 to September 2011, with implementation of the instruments HAQ II (health assessment questionnaire) and SF-36 (medical outcomes short-from health survey). Barlett test, Anova, Friedman and paired t-test were performed for multiple extracts. Results: 30 patients were evaluated, mean age of 47.6 (SD: 12.25) years and prevalence of females (90%). The mean score of HAQ II before treatment was 1.97, with significant reduction of up to 1.23 after six months of biological therapy (p<0.01). Most of the SF-36 domains showed significant improvement after six months of treatment (p<0.01), highlighting the social aspects, pain, physical functioning, emotional issues, vitality and physical aspects. Conclusion: the use of biologic therapy in patients with RA refractory to standard therapies proved to be an important pharmacological strategy for improving HRQL. |
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Associação Médica Brasileira |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000200126 |
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