Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine
ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 µg/kg of detomidine alone (IMD) and intramuscular administration of 30 µg/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn’s post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. IMDM promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD.
Main Authors: | , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Universidade Federal de Santa Maria
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0103-84782022000800601 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0103-847820220008006012021-12-21Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphineGaddini,Lucas ValeirasAlencar,Carlos Rodrigo Komatsu deAzevedo,Taina Lorraine PereiraLima,Gabriela Geraldo deTomacheuski,Rubia MitalliFerrante,MarcosTaffarel,Marilda Onghero deep sedation horses hypnotics and sedatives detomidine morphine ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 µg/kg of detomidine alone (IMD) and intramuscular administration of 30 µg/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn’s post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. IMDM promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD.info:eu-repo/semantics/openAccessUniversidade Federal de Santa MariaCiência Rural v.52 n.8 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601en10.1590/0103-8478cr20200828 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Gaddini,Lucas Valeiras Alencar,Carlos Rodrigo Komatsu de Azevedo,Taina Lorraine Pereira Lima,Gabriela Geraldo de Tomacheuski,Rubia Mitalli Ferrante,Marcos Taffarel,Marilda Onghero |
spellingShingle |
Gaddini,Lucas Valeiras Alencar,Carlos Rodrigo Komatsu de Azevedo,Taina Lorraine Pereira Lima,Gabriela Geraldo de Tomacheuski,Rubia Mitalli Ferrante,Marcos Taffarel,Marilda Onghero Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
author_facet |
Gaddini,Lucas Valeiras Alencar,Carlos Rodrigo Komatsu de Azevedo,Taina Lorraine Pereira Lima,Gabriela Geraldo de Tomacheuski,Rubia Mitalli Ferrante,Marcos Taffarel,Marilda Onghero |
author_sort |
Gaddini,Lucas Valeiras |
title |
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
title_short |
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
title_full |
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
title_fullStr |
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
title_full_unstemmed |
Sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
title_sort |
sedative effect and physiological changes in horses treated with intramuscular injection of detomidine and morphine |
description |
ABSTRACT: This study aimed to elucidate the sedative effect and physiological changes associated with the intramuscular injection of detomidine combined with morphine in horses. Six healthy crossbred horses, aged 2 to 10 years, were included. A crossover experimental design was used to compare the effects of intramuscular injection of 30 µg/kg of detomidine alone (IMD) and intramuscular administration of 30 µg/kg of detomidine and 0.1 mg/kg of morphine (IMDM). The degree of sedation, height of head above ground, were assessed at the time points before and 5, 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration, and heart rate, respiratory rate, systolic blood pressure, rectum temperature and intestinal motility were assessed at the time points before and 10, 20, 30, 40, 50, 60, 75, 90, 105, and 120 minutes after drug administration. The physiological parameters were analyzed using the Kruskal-Wallis test with Dunn’s post-hoc test and analysis of variance with t-test for independent samples and the sedation scores using the Friedman test and Mann Whitney U-test. P-values <0.05 indicated a statistically significant difference. IMDM promoted a higher sedative effect as compared to IMD, but the sedation occurred inconsistently. Additionally, a reduction in intestinal motility was observed with IMDM at 60, 75, 90, and 105 minutes after administration. IMDM promoted more variable sedation and prolonged reduction in the intestinal motility in the horses as compared to IMD. |
publisher |
Universidade Federal de Santa Maria |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000800601 |
work_keys_str_mv |
AT gaddinilucasvaleiras sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT alencarcarlosrodrigokomatsude sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT azevedotainalorrainepereira sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT limagabrielageraldode sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT tomacheuskirubiamitalli sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT ferrantemarcos sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine AT taffarelmarildaonghero sedativeeffectandphysiologicalchangesinhorsestreatedwithintramuscularinjectionofdetomidineandmorphine |
_version_ |
1756406629636505600 |