Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis
Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues.
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2018
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oai:scielo:S0103-644020180002001732018-06-07Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical PeriodontitisAzuma,Mariane MaffeiGomes-Filho,João EduardoCardoso,Carolina de Barros MoraisPipa,Camila BarbosaNarciso,Luis GustavoBomfim,Suely Regina MogamiJacinto,Rogério de CastilhoCintra,Luciano Tavares Angelo apical periodontitis lipid profile omega 3 fatty acids triglyceride levels cholesterol levels. Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues.info:eu-repo/semantics/openAccessFundação Odontológica de Ribeirão PretoBrazilian Dental Journal v.29 n.2 20182018-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200173en10.1590/0103-6440201801702 |
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Azuma,Mariane Maffei Gomes-Filho,João Eduardo Cardoso,Carolina de Barros Morais Pipa,Camila Barbosa Narciso,Luis Gustavo Bomfim,Suely Regina Mogami Jacinto,Rogério de Castilho Cintra,Luciano Tavares Angelo |
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Azuma,Mariane Maffei Gomes-Filho,João Eduardo Cardoso,Carolina de Barros Morais Pipa,Camila Barbosa Narciso,Luis Gustavo Bomfim,Suely Regina Mogami Jacinto,Rogério de Castilho Cintra,Luciano Tavares Angelo Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
author_facet |
Azuma,Mariane Maffei Gomes-Filho,João Eduardo Cardoso,Carolina de Barros Morais Pipa,Camila Barbosa Narciso,Luis Gustavo Bomfim,Suely Regina Mogami Jacinto,Rogério de Castilho Cintra,Luciano Tavares Angelo |
author_sort |
Azuma,Mariane Maffei |
title |
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
title_short |
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
title_full |
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
title_fullStr |
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
title_full_unstemmed |
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis |
title_sort |
omega 3 fatty acids reduce the triglyceride levels in rats with apical periodontitis |
description |
Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues. |
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Fundação Odontológica de Ribeirão Preto |
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2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200173 |
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