Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS’s clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

Saved in:
Bibliographic Details
Main Authors: Servato,João Paulo Silva, Faria,Paulo Rogério de, Ribeiro,Cássio Vinhadelli, Cardoso,Sergio Vitorino, Dias,Fernando Luiz, Eisenberg,Ana Lúcia Amaral, Loyola,Adriano Mota
Format: Digital revista
Language:English
Published: Fundação Odontológica de Ribeirão Preto 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200262
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items