DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression

DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression

Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.

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Main Authors: Bernardes,Vanessa Fátima, Odell,Edward W, Gomez,Ricardo Santiago, Gomes,Carolina Cavalieri
Format: Digital revista
Language:English
Published: Fundação Odontológica de Ribeirão Preto 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148
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spelling oai:scielo:S0103-644020170002001482018-02-01DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein ExpressionBernardes,Vanessa FátimaOdell,Edward WGomez,Ricardo SantiagoGomes,Carolina Cavalieri ubiquitin specific protease mucoepidermoid carcinoma adenoid cystic carcinoma polymorphous low grade adenocarcinoma carcinoma ex-pleomorphic adenoma epithelial-myoepithelial carcinoma. Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.info:eu-repo/semantics/openAccessFundação Odontológica de Ribeirão PretoBrazilian Dental Journal v.28 n.2 20172017-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148en10.1590/0103-6440201701018
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Bernardes,Vanessa Fátima
Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
spellingShingle Bernardes,Vanessa Fátima
Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
author_facet Bernardes,Vanessa Fátima
Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
author_sort Bernardes,Vanessa Fátima
title DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_short DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_full DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_fullStr DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_full_unstemmed DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_sort dna aneuploidy in malignant salivary gland neoplasms is independent of usp44 protein expression
description Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.
publisher Fundação Odontológica de Ribeirão Preto
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148
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AT odelledwardw dnaaneuploidyinmalignantsalivaryglandneoplasmsisindependentofusp44proteinexpression
AT gomezricardosantiago dnaaneuploidyinmalignantsalivaryglandneoplasmsisindependentofusp44proteinexpression
AT gomescarolinacavalieri dnaaneuploidyinmalignantsalivaryglandneoplasmsisindependentofusp44proteinexpression
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