Clonality analysis of giant cell lesions of the jaws
Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.
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Fundação Odontológica de Ribeirão Preto
2010
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oai:scielo:S0103-644020100004000132010-10-18Clonality analysis of giant cell lesions of the jawsAmaral,Fabrício RezendeGomes,Carolina CavaliériOliveira,Carla SilveiraSouza,Paulo Eduardo Alencar deGomez,Ricardo Santiago clonality clonal nature giant cell lesion giant cell granuloma HUMARA Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.info:eu-repo/semantics/openAccessFundação Odontológica de Ribeirão PretoBrazilian Dental Journal v.21 n.4 20102010-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013en10.1590/S0103-64402010000400013 |
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Amaral,Fabrício Rezende Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago |
| spellingShingle |
Amaral,Fabrício Rezende Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago Clonality analysis of giant cell lesions of the jaws |
| author_facet |
Amaral,Fabrício Rezende Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago |
| author_sort |
Amaral,Fabrício Rezende |
| title |
Clonality analysis of giant cell lesions of the jaws |
| title_short |
Clonality analysis of giant cell lesions of the jaws |
| title_full |
Clonality analysis of giant cell lesions of the jaws |
| title_fullStr |
Clonality analysis of giant cell lesions of the jaws |
| title_full_unstemmed |
Clonality analysis of giant cell lesions of the jaws |
| title_sort |
clonality analysis of giant cell lesions of the jaws |
| description |
Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions. |
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Fundação Odontológica de Ribeirão Preto |
| publishDate |
2010 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013 |
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| _version_ |
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