Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study

The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.

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Main Authors: Brandini,Daniela Atili, Sala,Miguel Angel, Lopes,Ruberval Armando, Semprini,Marisa, Contrera,Mary Garcia Duarte
Format: Digital revista
Language:English
Published: Fundação Odontológica de Ribeirão Preto 2005
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011
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spelling oai:scielo:S0103-644020050001000112005-08-17Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic studyBrandini,Daniela AtiliSala,Miguel AngelLopes,Ruberval ArmandoSemprini,MarisaContrera,Mary Garcia Duarte Meckel's cartilage cigarette smoke morphometry rat fetus The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.info:eu-repo/semantics/openAccessFundação Odontológica de Ribeirão PretoBrazilian Dental Journal v.16 n.1 20052005-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011en10.1590/S0103-64402005000100011
institution SCIELO
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country Brasil
countrycode BR
component Revista
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Brandini,Daniela Atili
Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
spellingShingle Brandini,Daniela Atili
Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
author_facet Brandini,Daniela Atili
Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
author_sort Brandini,Daniela Atili
title Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_short Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_full Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_fullStr Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_full_unstemmed Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_sort effects of cigarette smoke on the meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
description The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
publisher Fundação Odontológica de Ribeirão Preto
publishDate 2005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011
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