Partitioning evolutive standard base excess determinants in septic shock patients

Partitioning evolutive standard base excess determinants in septic shock patients

BACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin.

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Main Authors: Park,Marcelo, Noritomi,Danilo Teixeira, Toledo-Maciel,Alexandre, Azevedo,Luciano Cesar Pontes de, Pizzo,Vladimir Ribeiro, Cruz-Neto,Luiz Monteiro da
Format: Digital revista
Language:English
Published: Associação de Medicina Intensiva Brasileira - AMIB 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006
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spelling oai:scielo:S0103-507X20070004000062008-01-31Partitioning evolutive standard base excess determinants in septic shock patientsPark,MarceloNoritomi,Danilo TeixeiraToledo-Maciel,AlexandreAzevedo,Luciano Cesar Pontes dePizzo,Vladimir RibeiroCruz-Neto,Luiz Monteiro da lactate metabolic acidosis monitorization septic shock severe sepsis BACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin.info:eu-repo/semantics/openAccessAssociação de Medicina Intensiva Brasileira - AMIBRevista Brasileira de Terapia Intensiva v.19 n.4 20072007-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006en10.1590/S0103-507X2007000400006
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Park,Marcelo
Noritomi,Danilo Teixeira
Toledo-Maciel,Alexandre
Azevedo,Luciano Cesar Pontes de
Pizzo,Vladimir Ribeiro
Cruz-Neto,Luiz Monteiro da
spellingShingle Park,Marcelo
Noritomi,Danilo Teixeira
Toledo-Maciel,Alexandre
Azevedo,Luciano Cesar Pontes de
Pizzo,Vladimir Ribeiro
Cruz-Neto,Luiz Monteiro da
Partitioning evolutive standard base excess determinants in septic shock patients
author_facet Park,Marcelo
Noritomi,Danilo Teixeira
Toledo-Maciel,Alexandre
Azevedo,Luciano Cesar Pontes de
Pizzo,Vladimir Ribeiro
Cruz-Neto,Luiz Monteiro da
author_sort Park,Marcelo
title Partitioning evolutive standard base excess determinants in septic shock patients
title_short Partitioning evolutive standard base excess determinants in septic shock patients
title_full Partitioning evolutive standard base excess determinants in septic shock patients
title_fullStr Partitioning evolutive standard base excess determinants in septic shock patients
title_full_unstemmed Partitioning evolutive standard base excess determinants in septic shock patients
title_sort partitioning evolutive standard base excess determinants in septic shock patients
description BACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin.
publisher Associação de Medicina Intensiva Brasileira - AMIB
publishDate 2007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006
work_keys_str_mv AT parkmarcelo partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
AT noritomidaniloteixeira partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
AT toledomacielalexandre partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
AT azevedolucianocesarpontesde partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
AT pizzovladimirribeiro partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
AT cruznetoluizmonteiroda partitioningevolutivestandardbaseexcessdeterminantsinsepticshockpatients
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