Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics.
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Sociedade Brasileira de Química
2016
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oai:scielo:S0103-505320160008014652016-08-19Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production CapabilityAngolini,Célio F. F.Gonçalves,Ana B.Sigrist,RenataPaulo,Bruno S.Samborskyy,MarkiyanCruz,Pedro L. R.Vivian,Adriana F.Schmidt,Eduardo M.Eberlin,Marcos N.Araújo,Welington L.Oliveira,Luciana G. de genome sequencing genome mining molecular networking Streptomyces antibiotic activity The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.27 n.8 20162016-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801465en10.5935/0103-5053.20160180 |
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Angolini,Célio F. F. Gonçalves,Ana B. Sigrist,Renata Paulo,Bruno S. Samborskyy,Markiyan Cruz,Pedro L. R. Vivian,Adriana F. Schmidt,Eduardo M. Eberlin,Marcos N. Araújo,Welington L. Oliveira,Luciana G. de |
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Angolini,Célio F. F. Gonçalves,Ana B. Sigrist,Renata Paulo,Bruno S. Samborskyy,Markiyan Cruz,Pedro L. R. Vivian,Adriana F. Schmidt,Eduardo M. Eberlin,Marcos N. Araújo,Welington L. Oliveira,Luciana G. de Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
author_facet |
Angolini,Célio F. F. Gonçalves,Ana B. Sigrist,Renata Paulo,Bruno S. Samborskyy,Markiyan Cruz,Pedro L. R. Vivian,Adriana F. Schmidt,Eduardo M. Eberlin,Marcos N. Araújo,Welington L. Oliveira,Luciana G. de |
author_sort |
Angolini,Célio F. F. |
title |
Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
title_short |
Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
title_full |
Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
title_fullStr |
Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
title_full_unstemmed |
Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability |
title_sort |
genome mining of endophytic streptomyces wadayamensis reveals high antibiotic production capability |
description |
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics. |
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Sociedade Brasileira de Química |
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2016 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801465 |
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