New Alkaloids from Margaritopsis carrascoana (Rubiaceae)

New Alkaloids from Margaritopsis carrascoana (Rubiaceae)

Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods.

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Main Authors: Nascimento,Raimundo R. G., Pimenta,Antônia T. A., Lima Neto,Pedro de, C. Junior,José R., Costa-Lotufo,Letícia V., Ferreira,Elthon G., Tinoco,Luzineide W., Braz-Filho,Raimundo, Silveira,Edilberto R., Lima,Mary A. S.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601152
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spelling oai:scielo:S0103-505320150006011522020-06-05New Alkaloids from Margaritopsis carrascoana (Rubiaceae)Nascimento,Raimundo R. G.Pimenta,Antônia T. A.Lima Neto,Pedro deC. Junior,José R.Costa-Lotufo,Letícia V.Ferreira,Elthon G.Tinoco,Luzineide W.Braz-Filho,RaimundoSilveira,Edilberto R.Lima,Mary A. S. Margaritopsis carrascoana Rubiaceae alkaloids N-8”-methyl-N-1’-demethyliso-calycosidine N-8”-formyl-calycosidine calycosidine hodgkinsine Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.26 n.6 20152015-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601152en10.5935/0103-5053.20150079
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language English
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author Nascimento,Raimundo R. G.
Pimenta,Antônia T. A.
Lima Neto,Pedro de
C. Junior,José R.
Costa-Lotufo,Letícia V.
Ferreira,Elthon G.
Tinoco,Luzineide W.
Braz-Filho,Raimundo
Silveira,Edilberto R.
Lima,Mary A. S.
spellingShingle Nascimento,Raimundo R. G.
Pimenta,Antônia T. A.
Lima Neto,Pedro de
C. Junior,José R.
Costa-Lotufo,Letícia V.
Ferreira,Elthon G.
Tinoco,Luzineide W.
Braz-Filho,Raimundo
Silveira,Edilberto R.
Lima,Mary A. S.
New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
author_facet Nascimento,Raimundo R. G.
Pimenta,Antônia T. A.
Lima Neto,Pedro de
C. Junior,José R.
Costa-Lotufo,Letícia V.
Ferreira,Elthon G.
Tinoco,Luzineide W.
Braz-Filho,Raimundo
Silveira,Edilberto R.
Lima,Mary A. S.
author_sort Nascimento,Raimundo R. G.
title New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
title_short New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
title_full New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
title_fullStr New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
title_full_unstemmed New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
title_sort new alkaloids from margaritopsis carrascoana (rubiaceae)
description Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods.
publisher Sociedade Brasileira de Química
publishDate 2015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601152
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