Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity

Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity

Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.

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Main Authors: Amaral,Patricia de A., Petrignet,Julien, Gouault,Nicolas, Agustini,Taciane, Lohézic-Ledévéhat,Françoise, Cariou,Alexandre, Grée,René, Eifler-Lima,Vera L., David,Michèle
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2009
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018
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spelling oai:scielo:S0103-505320090009000182011-10-14Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activityAmaral,Patricia de A.Petrignet,JulienGouault,NicolasAgustini,TacianeLohézic-Ledévéhat,FrançoiseCariou,AlexandreGrée,RenéEifler-Lima,Vera L.David,Michèle δ-valerolactones kavaïn analogues Heck Sonogashira-Hagihara Suzuki-Miyaura tandem isomerization-aldolization cytotoxicity Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.20 n.9 20092009-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018en10.1590/S0103-50532009000900018
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
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region America del Sur
libraryname SciELO
language English
format Digital
author Amaral,Patricia de A.
Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
spellingShingle Amaral,Patricia de A.
Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
author_facet Amaral,Patricia de A.
Petrignet,Julien
Gouault,Nicolas
Agustini,Taciane
Lohézic-Ledévéhat,Françoise
Cariou,Alexandre
Grée,René
Eifler-Lima,Vera L.
David,Michèle
author_sort Amaral,Patricia de A.
title Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_short Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_full Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_fullStr Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_full_unstemmed Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
title_sort synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity
description Palladium-catalyzed cross coupling reactions (Sonogashira-Hagihara, Suzuki-Miyaura, and Heck) coupling and nickel hydride-mediated tandem isomerization aldolisation have been used for the synthesis of three series of δ-valerolactones substituted in positions 3, 4, 5 and 6 of the lactone ring. The 26 kavaïn-like derivatives were tested against three cell lines and five of them exhibited a weak cytotoxic activity.
publisher Sociedade Brasileira de Química
publishDate 2009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000900018
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