Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.

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Main Authors: Martins,Marcos A. P., Moreira,Dayse N., Frizzo,Clarissa P., Longhi,Kelvis, Zanatta,Nilo, Bonacorso,Helio G.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2008
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000700019
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spelling oai:scielo:S0103-505320080007000192017-05-05Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazideMartins,Marcos A. P.Moreira,Dayse N.Frizzo,Clarissa P.Longhi,KelvisZanatta,NiloBonacorso,Helio G. pyrazoline enones cyanoacetohydrazide cyclocondensation The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.19 n.7 20082008-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000700019en10.1590/S0103-50532008000700019
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country Brasil
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region America del Sur
libraryname SciELO
language English
format Digital
author Martins,Marcos A. P.
Moreira,Dayse N.
Frizzo,Clarissa P.
Longhi,Kelvis
Zanatta,Nilo
Bonacorso,Helio G.
spellingShingle Martins,Marcos A. P.
Moreira,Dayse N.
Frizzo,Clarissa P.
Longhi,Kelvis
Zanatta,Nilo
Bonacorso,Helio G.
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
author_facet Martins,Marcos A. P.
Moreira,Dayse N.
Frizzo,Clarissa P.
Longhi,Kelvis
Zanatta,Nilo
Bonacorso,Helio G.
author_sort Martins,Marcos A. P.
title Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
title_short Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
title_full Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
title_fullStr Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
title_full_unstemmed Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
title_sort reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
description The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.
publisher Sociedade Brasileira de Química
publishDate 2008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000700019
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