Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide
The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.
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Sociedade Brasileira de Química
2008
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oai:scielo:S0103-505320080007000192017-05-05Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazideMartins,Marcos A. P.Moreira,Dayse N.Frizzo,Clarissa P.Longhi,KelvisZanatta,NiloBonacorso,Helio G. pyrazoline enones cyanoacetohydrazide cyclocondensation The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.19 n.7 20082008-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000700019en10.1590/S0103-50532008000700019 |
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Martins,Marcos A. P. Moreira,Dayse N. Frizzo,Clarissa P. Longhi,Kelvis Zanatta,Nilo Bonacorso,Helio G. |
spellingShingle |
Martins,Marcos A. P. Moreira,Dayse N. Frizzo,Clarissa P. Longhi,Kelvis Zanatta,Nilo Bonacorso,Helio G. Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
author_facet |
Martins,Marcos A. P. Moreira,Dayse N. Frizzo,Clarissa P. Longhi,Kelvis Zanatta,Nilo Bonacorso,Helio G. |
author_sort |
Martins,Marcos A. P. |
title |
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
title_short |
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
title_full |
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
title_fullStr |
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
title_full_unstemmed |
Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
title_sort |
reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide |
description |
The synthesis of thirteen 1-cyanoacetyl-5-hydroxy-5-halomethyl-1H-4,5-dihydropyrazoles from the reaction of 4-alkoxy-3-alken-2-ones [R³C(O)C(R²)=C(R¹)(OR), where R³ = CF3, CCl3, CHCl2, CO2Et; R² = H, Me; R¹ = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. In order to show the versatility of using the 1-cyanoacetyl-substituted pyrazoles as important building blocks in organic synthesis, some attempts to obtain pyrazole derivatives also are described. |
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Sociedade Brasileira de Química |
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2008 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000700019 |
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