Electrochemical reduction and cathodic stripping voltammetric determination of clotrimazole
The reduction of clotrimazole at a mercury electrode, in phosphate buffer, pH>6, involves a reversible one-electron process. The electrochemical process presents a large contribution from adsorption effects. For the differential pulse polarographic determination the addition of Triton X-100 is recommended. Clotrimazole can be determined by cathodic stripping voltammetry at 50 ng mL-1 level when pre-accumulated for 3 min at an accumulation potential of -0.20 V. The proposed method is applied successfully for the determination of clotrimazole in a commercial formulation.
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| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2001
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000200013 |
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