NMR Spectroscopy, Hammett Correlations and Biological Activity of Some Schiff Bases Derived from Piperonal

A series of eleven Schiff Bases have been synthesized. They were obtained by condensation of piperonal (3,4-methylenedioxybenzaldehyde) with the corresponding aromatic primary amines. Their ¹H and 13C-NMR spectra have been obtained and the Hammett correlations including chemical shifts and the subsitutent constants (sigmap, sigmaR e sigmaI) were studied. Linear and bilinear significant correlations were observed for iminic carbon (C-alpha) and C-1’, showing a more significant ressonance effect on chemical shifts. The chemical shifts for C-4’ were highly affected by substituent effects, especially for halogens in the expected direction. Their biological activity against microorganisms has also been measured and significant activity was showed against Epidermophyton floccosum. The biological activity did not give a reasonable relationship with electronic effects.

Bibliographic Details

Main Authors:	Echevarria,Aurea, Nascimento,Maria da Graça, Gerônimo,Vanilde, Miller,Joseph, Giesbrecht,Astréa
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 1999
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000100010
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