Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature
Abstract Objective: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. Data source: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online (SciELO) databases with the descriptors “Cannabidiol” and “Epilepsy.” The search was not limited by the date of publication, language, or study design. A total of 69 articles were included in the review. Data synthesis: The efficacy of CBD in treating epileptic seizures has been confirmed by randomized controlled trials for Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. The incidence of side effects reported in subjects of the studies is high. However, most studies indicate a good safety profile and tolerance to the drug, with most of the adverse effects being mild to moderate and transient. Conclusions: There is no consensus on the release of CBD as a therapeutic tool by the drug regulatory agencies worldwide. However, the use of CBD is promising since it has presented satisfactory results in crisis control in well-designed studies. In addition, this drug has a good safety and tolerance profile. However, further studies with a long follow-up period are needed to confirm its usefulness and the long-term safety in pediatric patients.
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Sociedade de Pediatria de São Paulo
2023
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oai:scielo:S0103-058220230001005032022-07-01Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literatureMoreira,Gabriela AraujoMoraes Neto,RoddieRibeiro,Ricardo GullitCrippa,Ana Chrystina De Souza Epilepsy Cannabidiol Drug resistant epilepsy Child Adolescent Abstract Objective: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. Data source: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online (SciELO) databases with the descriptors “Cannabidiol” and “Epilepsy.” The search was not limited by the date of publication, language, or study design. A total of 69 articles were included in the review. Data synthesis: The efficacy of CBD in treating epileptic seizures has been confirmed by randomized controlled trials for Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. The incidence of side effects reported in subjects of the studies is high. However, most studies indicate a good safety profile and tolerance to the drug, with most of the adverse effects being mild to moderate and transient. Conclusions: There is no consensus on the release of CBD as a therapeutic tool by the drug regulatory agencies worldwide. However, the use of CBD is promising since it has presented satisfactory results in crisis control in well-designed studies. In addition, this drug has a good safety and tolerance profile. However, further studies with a long follow-up period are needed to confirm its usefulness and the long-term safety in pediatric patients.info:eu-repo/semantics/openAccessSociedade de Pediatria de São PauloRevista Paulista de Pediatria v.41 20232023-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822023000100503en10.1590/1984-0462/2023/41/2021197 |
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Moreira,Gabriela Araujo Moraes Neto,Roddie Ribeiro,Ricardo Gullit Crippa,Ana Chrystina De Souza |
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Moreira,Gabriela Araujo Moraes Neto,Roddie Ribeiro,Ricardo Gullit Crippa,Ana Chrystina De Souza Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
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Moreira,Gabriela Araujo Moraes Neto,Roddie Ribeiro,Ricardo Gullit Crippa,Ana Chrystina De Souza |
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Moreira,Gabriela Araujo |
title |
Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_short |
Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_full |
Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_fullStr |
Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
title_full_unstemmed |
Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
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cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature |
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Abstract Objective: The aim of this current report was to present a critical review of the use of cannabidiol (CBD) in the treatment of refractory epilepsies in the pediatric population. Data source: Literature review was carried out in the Medline (PubMed), Cochrane, and Scientific Electronic Library Online (SciELO) databases with the descriptors “Cannabidiol” and “Epilepsy.” The search was not limited by the date of publication, language, or study design. A total of 69 articles were included in the review. Data synthesis: The efficacy of CBD in treating epileptic seizures has been confirmed by randomized controlled trials for Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. The incidence of side effects reported in subjects of the studies is high. However, most studies indicate a good safety profile and tolerance to the drug, with most of the adverse effects being mild to moderate and transient. Conclusions: There is no consensus on the release of CBD as a therapeutic tool by the drug regulatory agencies worldwide. However, the use of CBD is promising since it has presented satisfactory results in crisis control in well-designed studies. In addition, this drug has a good safety and tolerance profile. However, further studies with a long follow-up period are needed to confirm its usefulness and the long-term safety in pediatric patients. |
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Sociedade de Pediatria de São Paulo |
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2023 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822023000100503 |
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