DNA damage in Wistar Kyoto rats exercised during pregnancy
Abstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2017
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oai:scielo:S0102-865020170005003882017-06-02DNA damage in Wistar Kyoto rats exercised during pregnancyCorrêa,Mikaela da SilvaGelaleti,Rafael BottaroBento,Giovana FernandaDamasceno,Débora CristinaPeraçoli,José Carlos Pregnancy Exercise DNA Damage Rats Abstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.32 n.5 20172017-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388en10.1590/s0102-865020170050000008 |
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Corrêa,Mikaela da Silva Gelaleti,Rafael Bottaro Bento,Giovana Fernanda Damasceno,Débora Cristina Peraçoli,José Carlos |
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Corrêa,Mikaela da Silva Gelaleti,Rafael Bottaro Bento,Giovana Fernanda Damasceno,Débora Cristina Peraçoli,José Carlos DNA damage in Wistar Kyoto rats exercised during pregnancy |
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Corrêa,Mikaela da Silva Gelaleti,Rafael Bottaro Bento,Giovana Fernanda Damasceno,Débora Cristina Peraçoli,José Carlos |
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Corrêa,Mikaela da Silva |
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DNA damage in Wistar Kyoto rats exercised during pregnancy |
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DNA damage in Wistar Kyoto rats exercised during pregnancy |
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DNA damage in Wistar Kyoto rats exercised during pregnancy |
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DNA damage in Wistar Kyoto rats exercised during pregnancy |
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DNA damage in Wistar Kyoto rats exercised during pregnancy |
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dna damage in wistar kyoto rats exercised during pregnancy |
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Abstract Purpose: To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program. Methods: Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage. Results: Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05). Conclusion: The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2017 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000500388 |
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