The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury
PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2015
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oai:scielo:S0102-865020150006004142015-10-08The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injuryTuglu,DevrimYuvanc,ErcanYılmaz,ErdalGencay,Isin YaziciAtasoy,PinarKisa,UclerBatislam,Ertan Dexmedetomidine Spermatic Cord Torsion Antioxidants Reperfusion Injury Testis Rats PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.30 n.6 20152015-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600414en10.1590/S0102-865020150060000007 |
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Tuglu,Devrim Yuvanc,Ercan Yılmaz,Erdal Gencay,Isin Yazici Atasoy,Pinar Kisa,Ucler Batislam,Ertan |
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Tuglu,Devrim Yuvanc,Ercan Yılmaz,Erdal Gencay,Isin Yazici Atasoy,Pinar Kisa,Ucler Batislam,Ertan The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
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Tuglu,Devrim Yuvanc,Ercan Yılmaz,Erdal Gencay,Isin Yazici Atasoy,Pinar Kisa,Ucler Batislam,Ertan |
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Tuglu,Devrim |
title |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
title_short |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
title_full |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
title_fullStr |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
title_full_unstemmed |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
title_sort |
antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury |
description |
PURPOSE:To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000600414 |
work_keys_str_mv |
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