Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2015
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oai:scielo:S0102-865020150004002702015-10-08Parecoxib reduces renal injury in an ischemia/reperfusion model in ratsCalistro Neto,José PedroTorres,Rômulo da CostaGonçalves,Giovanna MariaSilva,Leopoldo Muniz daDomingues,Maria Aparecida CustódioMódolo,Norma Sueli PinheiroBarros,Guilherme Antonio Moreira de Parecoxib Ischemia Reperfusion Kidney Rats PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.30 n.4 20152015-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270en10.1590/S0102-865020150040000006 |
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Calistro Neto,José Pedro Torres,Rômulo da Costa Gonçalves,Giovanna Maria Silva,Leopoldo Muniz da Domingues,Maria Aparecida Custódio Módolo,Norma Sueli Pinheiro Barros,Guilherme Antonio Moreira de |
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Calistro Neto,José Pedro Torres,Rômulo da Costa Gonçalves,Giovanna Maria Silva,Leopoldo Muniz da Domingues,Maria Aparecida Custódio Módolo,Norma Sueli Pinheiro Barros,Guilherme Antonio Moreira de Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
author_facet |
Calistro Neto,José Pedro Torres,Rômulo da Costa Gonçalves,Giovanna Maria Silva,Leopoldo Muniz da Domingues,Maria Aparecida Custódio Módolo,Norma Sueli Pinheiro Barros,Guilherme Antonio Moreira de |
author_sort |
Calistro Neto,José Pedro |
title |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
title_short |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
title_full |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
title_fullStr |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
title_full_unstemmed |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
title_sort |
parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
description |
PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publishDate |
2015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270 |
work_keys_str_mv |
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