Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014
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oai:scielo:S0102-865020140010006672015-07-31Progressive loss of E-cadherin immunoexpression during cervical carcinogenesisCavalcante,José RooseveltSampaio,João Paulo AguiarMaia Filho,João Tarcísio AlvesVieira,Renato BragaEleutério Júnior,JoséLima Júnior,Roberto César PereiraRibeiro,Ronaldo AlbuquerqueAlmeida,Paulo Roberto Carvalho Cadherins Immunohistochemistry Cervical Intraepithelial Neoplasia Neoplasms squamous cell Uterine Cervical Neoplasms PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.29 n.10 20142014-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001000667en10.1590/S0102-8650201400160007 |
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Cavalcante,José Roosevelt Sampaio,João Paulo Aguiar Maia Filho,João Tarcísio Alves Vieira,Renato Braga Eleutério Júnior,José Lima Júnior,Roberto César Pereira Ribeiro,Ronaldo Albuquerque Almeida,Paulo Roberto Carvalho |
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Cavalcante,José Roosevelt Sampaio,João Paulo Aguiar Maia Filho,João Tarcísio Alves Vieira,Renato Braga Eleutério Júnior,José Lima Júnior,Roberto César Pereira Ribeiro,Ronaldo Albuquerque Almeida,Paulo Roberto Carvalho Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
author_facet |
Cavalcante,José Roosevelt Sampaio,João Paulo Aguiar Maia Filho,João Tarcísio Alves Vieira,Renato Braga Eleutério Júnior,José Lima Júnior,Roberto César Pereira Ribeiro,Ronaldo Albuquerque Almeida,Paulo Roberto Carvalho |
author_sort |
Cavalcante,José Roosevelt |
title |
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
title_short |
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
title_full |
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
title_fullStr |
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
title_full_unstemmed |
Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis |
title_sort |
progressive loss of e-cadherin immunoexpression during cervical carcinogenesis |
description |
PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014001000667 |
work_keys_str_mv |
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