Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome
PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05.RESULTS:Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05).CONCLUSION:Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.
Main Authors: | Nacif,Lucas Souto, Andraus,Wellington, Kubrusly,Márcia Saldanha, Kubrusly,Flávia Saldanha, Gebara,Vera Cristina Bugelli Cainelli, Ishizawa,Andrea, D'Albuquerque,Luiz Augusto Carneiro |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900573 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The hepatopulmonary syndrome
by: NACIF,Lucas Souto, et al.
Published: (2014) -
Which is the best route of administration for cell therapy in experimental model of small-for size syndrome in rats?
by: Nacif,Lucas Souto, et al.
Published: (2015) -
Atividade da mieloperoxidase está aumentada na síndrome hepatopulmonar em ratos
by: Nacif,Lucas Souto, et al.
Published: (2013) -
Hepatopulmonary syndrome: an update
by: Macêdo,Liana Gonçalves de, et al.
Published: (2009) -
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome
by: Li,X., et al.
Published: (2016)