Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats
PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant.RESULTS:We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of post-implantation loss (RPIL) and rates of foetal viability (RFV).CONCLUSIONS:There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014
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oai:scielo:S0102-865020140007004102015-10-08Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar ratsFigueiró-Filho,Ernesto AntonioAydos,Ricardo DutraSenefonte,Flávio Renato de AlmeidaFerreira,Cristiane MunarettoPereira,Érica Freire de VasconcelosOliveira,Vanessa Marcon deMenezes,Giovanna Pádoa deBósio,Marco Antonio Costa Heparin Enoxaparin Fertility Pregnancy Rats PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant.RESULTS:We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of post-implantation loss (RPIL) and rates of foetal viability (RFV).CONCLUSIONS:There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.29 n.7 20142014-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700410en10.1590/S0102-86502014000700001 |
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Figueiró-Filho,Ernesto Antonio Aydos,Ricardo Dutra Senefonte,Flávio Renato de Almeida Ferreira,Cristiane Munaretto Pereira,Érica Freire de Vasconcelos Oliveira,Vanessa Marcon de Menezes,Giovanna Pádoa de Bósio,Marco Antonio Costa |
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Figueiró-Filho,Ernesto Antonio Aydos,Ricardo Dutra Senefonte,Flávio Renato de Almeida Ferreira,Cristiane Munaretto Pereira,Érica Freire de Vasconcelos Oliveira,Vanessa Marcon de Menezes,Giovanna Pádoa de Bósio,Marco Antonio Costa Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
author_facet |
Figueiró-Filho,Ernesto Antonio Aydos,Ricardo Dutra Senefonte,Flávio Renato de Almeida Ferreira,Cristiane Munaretto Pereira,Érica Freire de Vasconcelos Oliveira,Vanessa Marcon de Menezes,Giovanna Pádoa de Bósio,Marco Antonio Costa |
author_sort |
Figueiró-Filho,Ernesto Antonio |
title |
Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
title_short |
Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
title_full |
Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
title_fullStr |
Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
title_full_unstemmed |
Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female Wistar rats |
title_sort |
effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic doses on the fertility of female wistar rats |
description |
PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats.METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of live and dead foetuses was quantified. The uterine horns were dissected and the presence of early and late reabsorptions (abortions) was determined. A p<0.05 was considered statistically significant.RESULTS:We did not observe statistically significant differences between groups when comparing the average weight of the foetuses and placentas, rate of female VS males, rates of pre-implantation loss (RPL), rates of efficiency implantation (REI), rates of post-implantation loss (RPIL) and rates of foetal viability (RFV).CONCLUSIONS:There was no significant effect on fertility with the use of anticoagulant drugs in pregnant healthy Wistar rats. |
publisher |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publishDate |
2014 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000700410 |
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