Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs

PURPOSE: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.METHODS: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.RESULTS: Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.CONCLUSION: The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.

Bibliographic Details

Main Authors:	Yilmaz,Dincer, Dogan,Necdet, Ozkan,Aydin, Sencimen,Metin, Ora,Baris Eren, Mutlu,Ibrahim
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2014
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000100059
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