Hematological and hemostaseological alterations after warm and cold limb ischemia-reperfusion in a canine model
PURPOSE: Acute ischemia-reperfusion (I/R) of extremities means serious challenge in the clinical practice. Furthermore, the issue of preventive cooling is still controversial. In this canine model we investigated whether limb I/R -with or without cooling- has an influence on hematological and hemostaseological factors. METHODS: Femoral vessels were exposed and clamped for 3 hours. After release the clamps, 4-hour reperfusion was secured. The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. Before operations, from the excluded limb by the end of ischemia, during the reperfusion, and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters. RESULTS: After I/R activated partial thromboplastin time was elongated on 2nd-4th postoperative days. The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. The hematological parameters and fibrinogen level showed non-specific changes. In excluded ischemic limb the blood composition showed controversial data. Cold ischemia induced larger alterations, however platelet count, hematocrit changed more expressly in warm ischemia. CONCLUSION: These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R.
Main Authors: | Szokoly,Miklos, Nemeth,Norbert, Furka,Istvan, Miko,Iren |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2009
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000500002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Effects of allopurinol and preconditioning on apoptosis due to ischemia-reperfusion on a double jejunum-segment canine model
by: Brath,Endre, et al.
Published: (2011) -
Experiences with basic microsurgical training programs and skill assessment methods at the University of Debrecen, Hungary
by: Nemeth,Norbert, et al.
Published: (2018) -
Educational and research activity of the Department of Operative Techniques and Surgical Research, Institute of Surgery at the Medical and Health Science Center, University of Debrecen in Hungary
by: Nemeth,Norbert, et al.
Published: (2013) -
Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion
by: Klarik,Zoltan, et al.
Published: (2015) -
How does practice improve the skills of medical students during consecutive training courses?
by: Vanyolos,Erzsebet, et al.
Published: (2017)