Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant
PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2007
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oai:scielo:S0102-865020070007000102007-04-26Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplantSimões,Fernanda CorreiaMarques,Ruy GarciaDiestel,Cristina FajardoCaetano,Carlos Eduardo RodriguesDinis,Ana Paula GonçalvesHorst,Nara LimeiraNogueira Neto,José FirminoPortela,Margareth Crisóstomo Splenectomy Transplantation Lipid metabolism Animal feed PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.22 suppl.1 20072007-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010en10.1590/S0102-86502007000700010 |
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Simões,Fernanda Correia Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo |
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Simões,Fernanda Correia Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
author_facet |
Simões,Fernanda Correia Marques,Ruy Garcia Diestel,Cristina Fajardo Caetano,Carlos Eduardo Rodrigues Dinis,Ana Paula Gonçalves Horst,Nara Limeira Nogueira Neto,José Firmino Portela,Margareth Crisóstomo |
author_sort |
Simões,Fernanda Correia |
title |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_short |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_full |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_fullStr |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_full_unstemmed |
Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
title_sort |
lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant |
description |
PURPOSE: To evaluate the alterations on plasmatic lipids levels among rats submitted to total splenectomy isolated or combined with splenic autotransplant receiving standard chow during the postoperative period. METHODS: Thirty Wistar rats were divided into three groups: control (C) - sham-operated, total splenectomy - isolated (TS) or combined with splenic autotransplantation (SA). Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993). The plasmatic levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and glucose (GLUC) were analyzed before the surgical procedure and after 6 and 12 weeks. RESULTS: All the animals presented significant increase of TG and VLDL levels. In relation to the other parameters there was no difference among the weeks 0 and 12 in the animals of group C. In TS group significant increase was observed in TC and GLUC levels during the experiment. In SA group TC, HDL, and GLUC levels remained unaffected while HDL levels increased. CONCLUSION: Our findings suggest that isolated total splenectomy alters lipids metabolism in rats fed with standard chow and splenic autotransplantation is effective in restoring its control. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2007 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000700010 |
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