Cellular aspects of liver regeneration

This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a bypotential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocitic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ.

Bibliographic Details

Main Authors:	Tarlá,Marissa Rabelo, Ramalho,Fernando, Ramalho,Leandra Naira Zambelli, Castro e Silva,Tiago, Brandão,Daniel Ferracioli, Ferreira,Juliana, Castro e Silva,Orlando, Zucoloto,Sérgio
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2006
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000700015
Tags:	Add Tag No Tags, Be the first to tag this record!