Gastric proliferative lesions induced by duodenogastric reflux in rats
PURPOSE: To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats. METHODS: Seventy-five healthy and adult male rats were divided into three groups: group I - control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II - DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III - DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach. RESULTS: Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%). CONCLUSIONS: The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2006
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oai:scielo:S0102-865020060004000042006-09-20Gastric proliferative lesions induced by duodenogastric reflux in ratsMonteiro,Rosângela Lucinda RochaAndreollo,Nelson AdamiRodrigues,Maria Aparecida MarchesanAraujo,Marina Raquel Duodenogastric Reflux Hyperplasia Adenocarcinoma Rats PURPOSE: To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats. METHODS: Seventy-five healthy and adult male rats were divided into three groups: group I - control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II - DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III - DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach. RESULTS: Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%). CONCLUSIONS: The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.21 n.4 20062006-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400004en10.1590/S0102-86502006000400004 |
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Monteiro,Rosângela Lucinda Rocha Andreollo,Nelson Adami Rodrigues,Maria Aparecida Marchesan Araujo,Marina Raquel |
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Monteiro,Rosângela Lucinda Rocha Andreollo,Nelson Adami Rodrigues,Maria Aparecida Marchesan Araujo,Marina Raquel Gastric proliferative lesions induced by duodenogastric reflux in rats |
author_facet |
Monteiro,Rosângela Lucinda Rocha Andreollo,Nelson Adami Rodrigues,Maria Aparecida Marchesan Araujo,Marina Raquel |
author_sort |
Monteiro,Rosângela Lucinda Rocha |
title |
Gastric proliferative lesions induced by duodenogastric reflux in rats |
title_short |
Gastric proliferative lesions induced by duodenogastric reflux in rats |
title_full |
Gastric proliferative lesions induced by duodenogastric reflux in rats |
title_fullStr |
Gastric proliferative lesions induced by duodenogastric reflux in rats |
title_full_unstemmed |
Gastric proliferative lesions induced by duodenogastric reflux in rats |
title_sort |
gastric proliferative lesions induced by duodenogastric reflux in rats |
description |
PURPOSE: To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats. METHODS: Seventy-five healthy and adult male rats were divided into three groups: group I - control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II - DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III - DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach. RESULTS: Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%). CONCLUSIONS: The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2006 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400004 |
work_keys_str_mv |
AT monteirorosangelalucindarocha gastricproliferativelesionsinducedbyduodenogastricrefluxinrats AT andreollonelsonadami gastricproliferativelesionsinducedbyduodenogastricrefluxinrats AT rodriguesmariaaparecidamarchesan gastricproliferativelesionsinducedbyduodenogastricrefluxinrats AT araujomarinaraquel gastricproliferativelesionsinducedbyduodenogastricrefluxinrats |
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1756400809995665408 |