Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin

Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin

PURPOSE: To compare the efficacy and safety of a low molecular weight heparin (enoxaparin) with unfractionated heparin (UH) in this prophylaxis. METHODS: Seventy five patients (59 men and 16 women), undergoing major lower extremity amputation (30 above-knee and 45 below-knee), were randomized to be treated with subcutaneous UH (5,000 IU t.i.d.) or enoxaparin (40mg/day) during hospitalization. Prophylaxis was started 12 hours before surgery or, in emergency cases, in the first postoperative day. RESULTS: The two groups were comparable with regard to baseline characteristics. Evaluation of DVT was performed by daily clinical examination and by duplex scanning before and 5 to 8 days after surgery. DVT was documented in the operated limb in 9.75% in patients treated with enoxaparin and in 11.76% in patients treated with UH (p=0.92) and there was one bilateral thrombosis in each group . Bleeding complications were not observed in both groups. CONCLUSION: Enoxaparin and UH were both efficient and safe for the prophylaxis of DVT in patients submitted to lower extremity amputation.

Saved in:
Bibliographic Details
Main Authors: Lastória,Sidney, Rollo,Hamilton A., Yoshida,Winston Bonetti, Giannini,Mariangela, Moura,Regina, Maffei,Francisco H. A.
Format: Digital revista
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2006
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300011
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0102-86502006000300011
record_format ojs
spelling oai:scielo:S0102-865020060003000112006-05-26Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparinLastória,SidneyRollo,Hamilton A.Yoshida,Winston BonettiGiannini,MariangelaMoura,ReginaMaffei,Francisco H. A. Amputation Venous Thrombosis Heparin/Low-Molecular-Weight Prevention & Control PURPOSE: To compare the efficacy and safety of a low molecular weight heparin (enoxaparin) with unfractionated heparin (UH) in this prophylaxis. METHODS: Seventy five patients (59 men and 16 women), undergoing major lower extremity amputation (30 above-knee and 45 below-knee), were randomized to be treated with subcutaneous UH (5,000 IU t.i.d.) or enoxaparin (40mg/day) during hospitalization. Prophylaxis was started 12 hours before surgery or, in emergency cases, in the first postoperative day. RESULTS: The two groups were comparable with regard to baseline characteristics. Evaluation of DVT was performed by daily clinical examination and by duplex scanning before and 5 to 8 days after surgery. DVT was documented in the operated limb in 9.75% in patients treated with enoxaparin and in 11.76% in patients treated with UH (p=0.92) and there was one bilateral thrombosis in each group . Bleeding complications were not observed in both groups. CONCLUSION: Enoxaparin and UH were both efficient and safe for the prophylaxis of DVT in patients submitted to lower extremity amputation.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.21 n.3 20062006-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300011en10.1590/S0102-86502006000300011
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Lastória,Sidney
Rollo,Hamilton A.
Yoshida,Winston Bonetti
Giannini,Mariangela
Moura,Regina
Maffei,Francisco H. A.
spellingShingle Lastória,Sidney
Rollo,Hamilton A.
Yoshida,Winston Bonetti
Giannini,Mariangela
Moura,Regina
Maffei,Francisco H. A.
Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
author_facet Lastória,Sidney
Rollo,Hamilton A.
Yoshida,Winston Bonetti
Giannini,Mariangela
Moura,Regina
Maffei,Francisco H. A.
author_sort Lastória,Sidney
title Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
title_short Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
title_full Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
title_fullStr Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
title_full_unstemmed Prophylaxis of deep-vein thrombosis after lower extremity amputation: Comparison of low molecular weight heparin with unfractionated heparin
title_sort prophylaxis of deep-vein thrombosis after lower extremity amputation: comparison of low molecular weight heparin with unfractionated heparin
description PURPOSE: To compare the efficacy and safety of a low molecular weight heparin (enoxaparin) with unfractionated heparin (UH) in this prophylaxis. METHODS: Seventy five patients (59 men and 16 women), undergoing major lower extremity amputation (30 above-knee and 45 below-knee), were randomized to be treated with subcutaneous UH (5,000 IU t.i.d.) or enoxaparin (40mg/day) during hospitalization. Prophylaxis was started 12 hours before surgery or, in emergency cases, in the first postoperative day. RESULTS: The two groups were comparable with regard to baseline characteristics. Evaluation of DVT was performed by daily clinical examination and by duplex scanning before and 5 to 8 days after surgery. DVT was documented in the operated limb in 9.75% in patients treated with enoxaparin and in 11.76% in patients treated with UH (p=0.92) and there was one bilateral thrombosis in each group . Bleeding complications were not observed in both groups. CONCLUSION: Enoxaparin and UH were both efficient and safe for the prophylaxis of DVT in patients submitted to lower extremity amputation.
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate 2006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000300011
work_keys_str_mv AT lastoriasidney prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
AT rollohamiltona prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
AT yoshidawinstonbonetti prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
AT gianninimariangela prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
AT mouraregina prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
AT maffeifranciscoha prophylaxisofdeepveinthrombosisafterlowerextremityamputationcomparisonoflowmolecularweightheparinwithunfractionatedheparin
_version_ 1756400809308848128

Similar Items