Pathophysiology and Mechanisms of Saphenous Vein Graft Failure
ABSTRACT Introduction: Coronary artery bypass grafting remains one of the best therapies for advanced coronary artery disease. The most used conduit remains the great saphenous vein, which is susceptible to short-term and long-term failure, the result of acute thrombosis, intimal hyperplasia, and late superimposed atheroma. In this review, we present the current findings related to the pathophysiology of vein graft failure. Methods: A search of three databases - MEDLINE®, Web of Science™, and Cochrane Library - was undertaken for the terms “pathophysiology”, “prevention”, and “treatment” plus the term “vein graft failure”. Results: The pathophysiology of saphenous graft failure can be classified in three distinct phases - acute thrombosis, intimal hyperplasia, and accelerated atherosclerosis. All these processes start with an underlying histological predisposition of the vein and at the time of harvesting and preparation for grafting. These mechanisms are a result of localized inflammatory and prothrombotic cascades that obey different causes, but ultimately result in the stenosis or occlusion of the vein graft. Conclusion: The interaction between the different parts of the pathophysiology of vein graft failure is extremely complex and variable. Recent improvements in surgical techniques and secondary pharmaceutical prevention like early aspirin administration and long-term statin treatment have significantly reduced early and late saphenous vein graft failure. However, this continues to be a fascinating area of research with the potential for further improvement for patients and health service provision.
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Sociedade Brasileira de Cirurgia Cardiovascular
2022
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oai:scielo:S0102-763820220010000322022-09-02Pathophysiology and Mechanisms of Saphenous Vein Graft FailureGuida,Gustavo AntonioAngelini,Gianni D. Coronary Artery Bypass Coronary Artery Disease Atherosclerosis Inhibitors Hyperplasia Review. ABSTRACT Introduction: Coronary artery bypass grafting remains one of the best therapies for advanced coronary artery disease. The most used conduit remains the great saphenous vein, which is susceptible to short-term and long-term failure, the result of acute thrombosis, intimal hyperplasia, and late superimposed atheroma. In this review, we present the current findings related to the pathophysiology of vein graft failure. Methods: A search of three databases - MEDLINE®, Web of Science™, and Cochrane Library - was undertaken for the terms “pathophysiology”, “prevention”, and “treatment” plus the term “vein graft failure”. Results: The pathophysiology of saphenous graft failure can be classified in three distinct phases - acute thrombosis, intimal hyperplasia, and accelerated atherosclerosis. All these processes start with an underlying histological predisposition of the vein and at the time of harvesting and preparation for grafting. These mechanisms are a result of localized inflammatory and prothrombotic cascades that obey different causes, but ultimately result in the stenosis or occlusion of the vein graft. Conclusion: The interaction between the different parts of the pathophysiology of vein graft failure is extremely complex and variable. Recent improvements in surgical techniques and secondary pharmaceutical prevention like early aspirin administration and long-term statin treatment have significantly reduced early and late saphenous vein graft failure. However, this continues to be a fascinating area of research with the potential for further improvement for patients and health service provision.info:eu-repo/semantics/openAccessSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery v.37 n.spe1 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022001000032en10.21470/1678-9741-2022-0133 |
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Guida,Gustavo Antonio Angelini,Gianni D. |
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Guida,Gustavo Antonio Angelini,Gianni D. Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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Guida,Gustavo Antonio Angelini,Gianni D. |
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Guida,Gustavo Antonio |
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Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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Pathophysiology and Mechanisms of Saphenous Vein Graft Failure |
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pathophysiology and mechanisms of saphenous vein graft failure |
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ABSTRACT Introduction: Coronary artery bypass grafting remains one of the best therapies for advanced coronary artery disease. The most used conduit remains the great saphenous vein, which is susceptible to short-term and long-term failure, the result of acute thrombosis, intimal hyperplasia, and late superimposed atheroma. In this review, we present the current findings related to the pathophysiology of vein graft failure. Methods: A search of three databases - MEDLINE®, Web of Science™, and Cochrane Library - was undertaken for the terms “pathophysiology”, “prevention”, and “treatment” plus the term “vein graft failure”. Results: The pathophysiology of saphenous graft failure can be classified in three distinct phases - acute thrombosis, intimal hyperplasia, and accelerated atherosclerosis. All these processes start with an underlying histological predisposition of the vein and at the time of harvesting and preparation for grafting. These mechanisms are a result of localized inflammatory and prothrombotic cascades that obey different causes, but ultimately result in the stenosis or occlusion of the vein graft. Conclusion: The interaction between the different parts of the pathophysiology of vein graft failure is extremely complex and variable. Recent improvements in surgical techniques and secondary pharmaceutical prevention like early aspirin administration and long-term statin treatment have significantly reduced early and late saphenous vein graft failure. However, this continues to be a fascinating area of research with the potential for further improvement for patients and health service provision. |
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Sociedade Brasileira de Cirurgia Cardiovascular |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382022001000032 |
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AT guidagustavoantonio pathophysiologyandmechanismsofsaphenousveingraftfailure AT angelinigiannid pathophysiologyandmechanismsofsaphenousveingraftfailure |
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