Near-fatal pulmonary embolism in an experimental model: hemodynamic, gasometric and capnographic variables
INTRODUCTION: Experimental studies on pulmonary embolism (PE) are usually performed under mechanical ventilation. Most patients with suspicion of PE enter the Emergency Services in spontaneous breathing and environmental air. Thus, under these conditions, measurements of hemodynamic, gasometric and capnographic variables contribute largely to a more specific comprehension of cardiopulmonary and gasometric alterations in the acute phase of the disease. Studies which evaluated animals under conditions are lacking. OBJECTIVE: This study aimed to submit animals under spontaneous ventilation and without supplemental oxygen to PE. METHODS: PE was induced in six pigs using autologous blood clots, and cardiorespiratory and gasometric records were performed before and after PE. The values of "near fatal" mean pulmonary arterial pressure (MPAP) were previously determined. RESULTS: The presence of obstructive shock could be evidenced by increased MPAP (from 17.8±3.5 to 41.7±3.3 mmHg) (P<0.0001) and decreased cardiac output (from 4.9±1.0 to 2.7±1.0 L/min) (P<0.003). Consequently, metabolic acidosis occurred (Lac art) (from 2.4±0.6 to 5.7±1.8 mmol/L)(P<0.0001). It was observed hypoxemia (from 73.5±12.7 to 40.3±4.6 mmHg) (P<0.0001); however, PaCO2 did not vary (from 44.9±4.4 to 48.2±6.0 mmHg) (NS). There were significant increases in both P(a-et)CO2 (from 4.8±2.8 to 37.2±5.8 mmHg) and P(A-a)O2 (from 8.2±8.9 to 37.2±10.3 mmHg) (both P<0.0001). There was also a significant increase in the total alveolar minute volume (from 4.0±0.9 to 10.6±2.9 L/min) (P<0.0001). CONCLUSIONS: In this model, the near fatal MPAP was from 2 to 2.5 times the basal MPAP; and the capnographic variables, associated with arterial and venous gasometry, showed effective in discriminating an acute obstructive profile.
Main Authors: | Pereira,Daniel José, Moreira,Marcos Mello, Paschoal,Ilma Aparecida, Martins,Luiz Cláudio, Metze,Konradin, Moreno Junior,Heitor |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2011
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382011000300023 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Near-fatal pulmonary embolism: capnographic perspective
by: Moreira,Marcos Mello, et al.
Published: (2018) -
Hemodynamic, ventilatory and gasometric evaluation of an experimental bronchopleural fistula
by: Oliveira,Douglas Guimaraes de, et al.
Published: (2015) -
Hemodynamic parameters and neurogenic pulmonary edema following spinal cord injury: an experimental model
by: Leal Filho,Manoel Baldoino, et al.
Published: (2005) -
Repercussion of brief hyperventilation manuever on the cerebral and systemic hemodynamic and gasometric parameters in mechanically ventilated patients
by: Cerqueira,Telma Cristina Fontes
Published: (2006) -
Sleep pattern in patients with Chronic Obstructive Pulmonary Disease and correlation among gasometric, spirometric, and polysomnographic variables
by: Santos,Carlos Eduardo Ventura Gaio dos, et al.
Published: (2003)