Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis
The genus Drimys presents the widest geographical distribution of the Winteraceae family, which comprises seven genera and about 120 species. In Brazil, the genus is found from Bahia to Rio Grande do Sul and occur in two species, Drimys angustifolia Miers, and D. brasiliensis Miers, Winteraceae, popularly known as "casca-de-anta", characterized by the presence of flavonoids and essential oils. It is used in folk medicine as an antiscorbutic, stimulant, antispasmodic, anti-diarrheal, antipyretic, antibacterial, and against asthma and bronchitis, besides having insecticidal properties. In addition to the known biological activities, it is very important to explore new applications in the treatment of physiological disorders or diseases caused by parasites. Based on this information, in this study we propose to evaluate volatile oils of the species D. brasiliensis and D. angustifolia, as an antioxidant, using the model of the DPPH radical as an antiviral against human herpes virus type 1 (HSV-1) and acute toxicity in vivo. The two species were not able to reduce the DPPH radical and showed interesting antiviral activity, significantly reducing the virus titers in vitro assays. Regarding the in vivo toxicity in female Wistar rats, treatment with the two species showed interesting signs in animals such as salivation, ptosis, tremor, decreased motor activity. In addition the oils of D. brasiliensis to other signs, some animals showed increased urination and diarrhea.
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Sociedade Brasileira de Farmacognosia
2013
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oai:scielo:S0102-695X20130002000132013-03-27Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensisGomes,Madson Ralide FonsecaSchuh,Roselena SilvestriJacques,Ana Laura BemvenutiDorneles,Gilcéia G.Montanha,JarbasRoehe,Paulo MichelBordignon,SérgioDallegrave,ElianeLeal,Mirna B.Limberger,Renata Pereira acute toxicity antioxidant antiviral Drimys angustifolia Drimys brasiliensis essential oils The genus Drimys presents the widest geographical distribution of the Winteraceae family, which comprises seven genera and about 120 species. In Brazil, the genus is found from Bahia to Rio Grande do Sul and occur in two species, Drimys angustifolia Miers, and D. brasiliensis Miers, Winteraceae, popularly known as "casca-de-anta", characterized by the presence of flavonoids and essential oils. It is used in folk medicine as an antiscorbutic, stimulant, antispasmodic, anti-diarrheal, antipyretic, antibacterial, and against asthma and bronchitis, besides having insecticidal properties. In addition to the known biological activities, it is very important to explore new applications in the treatment of physiological disorders or diseases caused by parasites. Based on this information, in this study we propose to evaluate volatile oils of the species D. brasiliensis and D. angustifolia, as an antioxidant, using the model of the DPPH radical as an antiviral against human herpes virus type 1 (HSV-1) and acute toxicity in vivo. The two species were not able to reduce the DPPH radical and showed interesting antiviral activity, significantly reducing the virus titers in vitro assays. Regarding the in vivo toxicity in female Wistar rats, treatment with the two species showed interesting signs in animals such as salivation, ptosis, tremor, decreased motor activity. In addition the oils of D. brasiliensis to other signs, some animals showed increased urination and diarrhea.info:eu-repo/semantics/openAccessSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.23 n.2 20132013-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200013en10.1590/S0102-695X2012005000142 |
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Gomes,Madson Ralide Fonseca Schuh,Roselena Silvestri Jacques,Ana Laura Bemvenuti Dorneles,Gilcéia G. Montanha,Jarbas Roehe,Paulo Michel Bordignon,Sérgio Dallegrave,Eliane Leal,Mirna B. Limberger,Renata Pereira |
| spellingShingle |
Gomes,Madson Ralide Fonseca Schuh,Roselena Silvestri Jacques,Ana Laura Bemvenuti Dorneles,Gilcéia G. Montanha,Jarbas Roehe,Paulo Michel Bordignon,Sérgio Dallegrave,Eliane Leal,Mirna B. Limberger,Renata Pereira Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| author_facet |
Gomes,Madson Ralide Fonseca Schuh,Roselena Silvestri Jacques,Ana Laura Bemvenuti Dorneles,Gilcéia G. Montanha,Jarbas Roehe,Paulo Michel Bordignon,Sérgio Dallegrave,Eliane Leal,Mirna B. Limberger,Renata Pereira |
| author_sort |
Gomes,Madson Ralide Fonseca |
| title |
Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| title_short |
Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| title_full |
Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| title_fullStr |
Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| title_full_unstemmed |
Biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from Drimys angustifolia and D. brasiliensis |
| title_sort |
biological assessment (antiviral and antioxidant) and acute toxicity of essential oils from drimys angustifolia and d. brasiliensis |
| description |
The genus Drimys presents the widest geographical distribution of the Winteraceae family, which comprises seven genera and about 120 species. In Brazil, the genus is found from Bahia to Rio Grande do Sul and occur in two species, Drimys angustifolia Miers, and D. brasiliensis Miers, Winteraceae, popularly known as "casca-de-anta", characterized by the presence of flavonoids and essential oils. It is used in folk medicine as an antiscorbutic, stimulant, antispasmodic, anti-diarrheal, antipyretic, antibacterial, and against asthma and bronchitis, besides having insecticidal properties. In addition to the known biological activities, it is very important to explore new applications in the treatment of physiological disorders or diseases caused by parasites. Based on this information, in this study we propose to evaluate volatile oils of the species D. brasiliensis and D. angustifolia, as an antioxidant, using the model of the DPPH radical as an antiviral against human herpes virus type 1 (HSV-1) and acute toxicity in vivo. The two species were not able to reduce the DPPH radical and showed interesting antiviral activity, significantly reducing the virus titers in vitro assays. Regarding the in vivo toxicity in female Wistar rats, treatment with the two species showed interesting signs in animals such as salivation, ptosis, tremor, decreased motor activity. In addition the oils of D. brasiliensis to other signs, some animals showed increased urination and diarrhea. |
| publisher |
Sociedade Brasileira de Farmacognosia |
| publishDate |
2013 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200013 |
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